- cleft palate / MGI
- absent tooth placode / MGI
- kyphosis / MGI
- decreased cell proliferation / MGI
- absent hair follicles / MGI
- decreased hair follicle number / MGI
- alopecia / MGI
- abnormal craniofacial morphology / MGI
- abnormal esophageal epithelium morphology / MGI
- abnormal esophageal squamous epithelium morphology / MGI
- abnormal stomach epithelium morphology / MGI
- abnormal stomach non-glandular epithelium morphology / MGI
- abnormal rectum morphology / MGI
- rectal prolapse / MGI
- distended urinary bladder / MGI
- abnormal urinary bladder urothelium morphology / MGI
- absent urinary bladder urothelium / MGI
- thin urinary bladder urothelium / MGI
- absent limbs / MGI
- abnormal forelimb morphology / MGI
- absent radius / MGI
- absent carpal bone / MGI
- absent hindlimb / MGI
- adactyly / MGI
- absent salivary gland / MGI
- absent mammary gland / MGI
- absent sebaceous gland / MGI
- enlarged lymph nodes / MGI
- weakness / MGI
- abnormal tongue epithelium morphology / MGI
- absent tongue squamous epithelium / MGI
- abnormal female reproductive system morphology / MGI
- abnormal uterine cervix epithelium morphology / MGI
- abnormal vagina epithelium morphology / MGI
- absent prostate gland / MGI
- abnormal skin condition / MGI
- shiny skin / MGI
- translucent skin / MGI
- blistering / MGI
- spontaneous skin ulceration / MGI
- wrinkled skin / MGI
- skin lesions / MGI
- abnormal epidermal layer morphology / MGI
- absent epidermis / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum spinosum morphology / MGI
- absent epidermis stratum corneum / MGI
- distended abdomen / MGI
- absent vibrissae / MGI
- absent eyelids / MGI
- absent lacrimal glands / MGI
- circling / MGI
- dehydration / MGI
- abnormal embryo development / MGI
- abnormal ectoderm development / MGI
- abnormal apical ectodermal ridge morphology / MGI
- absent apical ectodermal ridge / MGI
- impaired wound healing / MGI
- kidney inflammation / MGI
- acanthosis / MGI
- hemorrhage / MGI
- neoplasm / MGI
- increased malignant tumor incidence / MGI
- increased tumor incidence / MGI
- increased lung adenoma incidence / MGI
- abnormal skin morphology / MGI
- premature death / MGI
- abnormal limb morphology / MGI
- abnormal limb bone morphology / MGI
- abnormal reproductive system morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal tracheal ciliated epithelium morphology / MGI
- increased susceptibility to infection / MGI
- small uterus / MGI
- abnormal keratinocyte morphology / MGI
- abnormal keratinocyte differentiation / MGI
- impaired skin barrier function / MGI
- no phenotypic analysis / MGI
- abnormal septation of the cloaca / MGI
- abnormal esophagus development / MGI
- abnormal abdominal wall morphology / MGI
- rectovaginal fistula / MGI
- abnormal ventral body wall morphology / MGI
- abnormal keratinocyte physiology / MGI
- absent oviduct / MGI
- absent ovary / MGI
- kidney cysts / MGI
- abnormal hair follicle development / MGI
- abnormal facial morphology / MGI
- premature aging / MGI
- abnormal hair shaft morphology / MGI
- abnormal craniofacial development / MGI
- abnormal skin development / MGI
- aneuploidy / MGI
- decreased fetal size / MGI
- increased squamous cell carcinoma incidence / MGI
- decreased cellular sensitivity to ionizing radiation / MGI
- absent ulna / MGI
- abnormal pelvic girdle bone morphology / MGI
- small maxilla / MGI
- small limb buds / MGI
- small mandible / MGI
- intervertebral disk degeneration / MGI
- abnormal anus morphology / MGI
- gastric metaplasia / MGI
- ectrodactyly / MGI
- abnormal humerus morphology / MGI
- abnormal phalanx morphology / MGI
- muscle phenotype / MGI
- embryo phenotype / MGI
- reproductive system phenotype / MGI
- esophagogastric junction metaplasia / MGI
- abnormal skin physiology / MGI
- abnormal limb bud morphology / MGI
- abnormal corneal epithelium morphology / MGI
- abnormal mitochondrial physiology / MGI
- increased apoptosis / MGI
- decreased apoptosis / MGI
- abnormal limb development / MGI
- abnormal cellular replicative senescence / MGI
- early cellular replicative senescence / MGI
- abnormal olfactory epithelium morphology / MGI
- chromosomal instability / MGI
- clitoris hypoplasia / MGI
- uterine cervix inflammation / MGI
- increased histiocytic sarcoma incidence / MGI
- absent epidermis stratum granulosum / MGI
- decreased keratinocyte proliferation / MGI
- absent epidermis stratum spinosum / MGI
- abnormal secondary palate development / MGI
- abnormal prostate gland branching morphogenesis / MGI
- abnormal primitive urogenital sinus morphology / MGI
- umbilical hernia / MGI
- mortality/aging / MGI
- gastric cysts / MGI
- abnormal respiratory epithelium morphology / MGI
- neonatal lethality, complete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, incomplete penetrance / MGI
- dermal-epidermal separation / MGI
- abnormal urinary bladder detrusor smooth muscle morphology / MGI
- small tail bud / MGI
- abnormal olfactory gland morphology / MGI
- abnormal horizontal basal cell of olfactory epithelium morphology / MGI
- urinary bladder exstrophy / MGI
- absent pubic symphysis / MGI
- absent teeth / MGI
B6.Cg-Trp63tm1.1Gml/Cnrm
Status | Available to order |
EMMA ID | EM:13212 |
International strain name | B6.Cg-Trp63tm1.1Gml/Cnrm |
Alternative name | Delta13Trp63+/- |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Trp63tm1.1Ozg |
Gene/Transgene symbol | Trp63 |
Information from provider
Provider | Eleonora Candi |
Provider affiliation | Experimental Medicine, University of Roma "Tor Vergata" |
Genetic information | Heterozygous mice for deletion of exon 13 of Trp63 locus. Exon 13 was subjected to a cre-mediated deletion then the resulting allele is able to drive the expression of p63beta isoform instead of p63alpha. |
Phenotypic information | Homozygous:Homozygous mice are not available.Heterozygous:Heterozygous females are sterile, so it was not possible to obtain a homozygous strain. Male mice are fertile. Other phenotypic features are under investigation. |
Breeding history | Mice with Trp63 exon 13 floxed allele were generated by Ozgene (Ozgene Pty Ltd, Bentley, Australia), and the floxed/+ colony was amplified by crossing with wild-type C57BL/6J mice. Heterozygous floxed/+ mice were crossed with Tg(CMV-cre)1Cgn homozygous mice to obtain the p63 exon 13 deleted allele (Delta13p63). The Delta13p63/CMV-cre heterozygous mice were backcrossed with wild-type C57BL/6J mice to remove the CMV-cre allele. |
References |
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Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- The p63 C-terminus is essential for murine oocyte integrity.;Lena Anna Maria, Rossi Valerio, Osterburg Susanne, Smirnov Artem, Osterburg Christian, Tuppi Marcel, Cappello Angela, Amelio Ivano, Dötsch Volker, De Felici Massimo, Klinger Francesca Gioia, Annicchiarico-Petruzzelli Margherita, Valensise Herbert, Melino Gerry, Candi Eleonora, ;2021;Nature communications;12;383; 33452256
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