B6N.Cg-Slc6a3tm1(cre)Lrsn/Kctt

Status

Available to order

EMMA IDEM:13209
International strain nameB6N.Cg-Slc6a3tm1(cre)Lrsn/Kctt
Alternative nameDat-cre
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolSlc6a3tm1(cre)Lrsn
Gene/Transgene symbolSlc6a3

Information from provider

ProviderNils-Göran Larsson
Provider affiliationKarolinska Institutet
Genetic informationA cassette encoding NLS-cre recombinase (cre) followed by an FRT-flanked neomycin cassette was inserted upstream of the translation start codon in exon 2 of the mouse dopamine transporter gene (Slc6a3 or Dat). The neo cassette has been removed by breeding the original mouse line to FLPe deleter mice. The generation of this mutant has been described in Ekstrand et al., 2007. MitoPark mice can be generated by crossing this line (EM:13209, Dat-cre) to the Tfam loxP line (EM:13208). See Ekstrand et al., 2007 for further details.
Phenotypic informationHomozygous:
Viable and fertile

Heterozygous:
Viable and fertile
Breeding historyMales used for sperm freezing are on C57BL/6N background (at least 10 generations of backcrossing).
References
  • VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation.;Birgner Carolina, Nordenankar Karin, Lundblad Martin, Mendez José Alfredo, Smith Casey, le Grevès Madeleine, Galter Dagmar, Olson Lars, Fredriksson Anders, Trudeau Louis-Eric, Kullander Klas, Wallén-Mackenzie Asa, ;2010;Proceedings of the National Academy of Sciences of the United States of America;107;389-94; 20018672
  • Enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of VGLUT2 in midbrain dopamine neurons in mice.;Alsiö Johan, Nordenankar Karin, Arvidsson Emma, Birgner Carolina, Mahmoudi Souha, Halbout Briac, Smith Casey, Fortin Guillaume M, Olson Lars, Descarries Laurent, Trudeau Louis-Éric, Kullander Klas, Lévesque Daniel, Wallén-Mackenzie Asa, ;2011;The Journal of neuroscience : the official journal of the Society for Neuroscience;31;12593-603; 21880920
  • Mitochondrial Dysfunction Combined with High Calcium Load Leads to Impaired Antioxidant Defense Underlying the Selective Loss of Nigral Dopaminergic Neurons.;Ricke Konrad M, Paß Thomas, Kimoloi Sammy, Fährmann Kai, Jüngst Christian, Schauss Astrid, Baris Olivier R, Aradjanski Marijana, Trifunovic Aleksandra, Eriksson Faelker Therese M, Bergami Matteo, Wiesner Rudolf J, ;2020;The Journal of neuroscience : the official journal of the Society for Neuroscience;40;1975-1986; 32005765
  • Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction.;Kao Chung-Yang, Xu Mafei, Wang Leiming, Lin Shih-Chieh, Lee Hui-Ju, Duraine Lita, Bellen Hugo J, Goldstein David S, Tsai Sophia Y, Tsai Ming-Jer, ;2020;PLoS genetics;16;e1008868; 32579581
  • MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson's disease.;Ghaisas Shivani, Langley Monica R, Palanisamy Bharathi N, Dutta Somak, Narayanaswamy Kirthi, Plummer Paul J, Sarkar Souvarish, Ay Muhammet, Jin Huajun, Anantharam Vellareddy, Kanthasamy Arthi, Kanthasamy Anumantha G, ;2019;Neurotoxicology;75;186-199; 31505196
  • Cerebrospinal fluid neurofilament light chain as a biomarker of neurodegeneration in the Tg4510 and MitoPark mouse models.;Clement Amalie, Mitchelmore Cathy, Andersson Daniel R, Asuni Ayodeji A, ;2017;Neuroscience;354;101-109; 28461218
  • Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson's Disease.;Chen Cang, Guderyon Michael J, Li Yang, Ge Guo, Bhattacharjee Anindita, Ballard Cori, He Zhixu, Masliah Eliezer, Clark Robert A, O'Connor Jason C, Li Senlin, ;2020;Molecular therapy. Methods & clinical development;17;83-98; 31890743
  • Chronic A2A antagonist treatment alleviates parkinsonian locomotor deficiency in MitoPark mice.;Marcellino Daniel, Lindqvist Eva, Schneider Marion, Müller Christa E, Fuxe Kjell, Olson Lars, Galter Dagmar, ;2010;Neurobiology of disease;40;460-6; 20656029
  • Progressively disrupted somatodendritic morphology in dopamine neurons in a mouse Parkinson's model.;Lynch William B, Tschumi Christopher W, Sharpe Amanda L, Branch Sarah Y, Chen Cang, Ge Guo, Li Senlin, Beckstead Michael J, ;2018;Movement disorders : official journal of the Movement Disorder Society;33;1928-1937; 30440089
  • MitoPark mice, an animal model of Parkinson's disease, show enhanced prepulse inhibition of acoustic startle and no loss of gating in response to the adenosine A(2A) antagonist SCH 412348.;Grauer Steven M, Hodgson Robert, Hyde Lynn A, ;2014;Psychopharmacology;231;1325-37; 24150248
  • A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease.;Le Poul Emmanuel, Boléa Christelle, Girard Francoise, Poli Sonia, Charvin Delphine, Campo Brice, Bortoli Julien, Bessif Abdhelak, Luo Bin, Koser Amy Jo, Hodge Lisa M, Smith Karen M, DiLella Anthony G, Liverton Nigel, Hess Fred, Browne Susan E, Reynolds Ian J, ;2012;The Journal of pharmacology and experimental therapeutics;343;167-77; 22787118
  • Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.;Westerlund Marie, Ran Caroline, Borgkvist Anders, Sterky Fredrik H, Lindqvist Eva, Lundströmer Karin, Pernold Karin, Brené Stefan, Kallunki Pekka, Fisone Gilberto, Olson Lars, Galter Dagmar, ;2008;Molecular and cellular neurosciences;39;586-91; 18790059
  • Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease.;Good Cameron H, Hoffman Alexander F, Hoffer Barry J, Chefer Vladimir I, Shippenberg Toni S, Bäckman Cristina M, Larsson Nils-Göran, Olson Lars, Gellhaar Sandra, Galter Dagmar, Lupica Carl R, ;2011;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;25;1333-44; 21233488
  • Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons.;Ekstrand Mats I, Terzioglu Mügen, Galter Dagmar, Zhu Shunwei, Hofstetter Christoph, Lindqvist Eva, Thams Sebastian, Bergstrand Anita, Hansson Fredrik Sterky, Trifunovic Aleksandra, Hoffer Barry, Cullheim Staffan, Mohammed Abdul H, Olson Lars, Larsson Nils-Göran, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;1325-30; 17227870
  • MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease.;Galter D, Pernold K, Yoshitake T, Lindqvist E, Hoffer B, Kehr J, Larsson N-G, Olson L, ;2010;Genes, brain, and behavior;9;173-81; 20002202
  • Chronic L-DOPA induces hyperactivity, normalization of gait and dyskinetic behavior in MitoPark mice.;Gellhaar S, Marcellino D, Abrams M B, Galter D, ;2015;Genes, brain, and behavior;14;260-70; 25752644
  • MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.;Fell Matthew J, Mirescu Christian, Basu Kallol, Cheewatrakoolpong Boonlert, DeMong Duane E, Ellis J Michael, Hyde Lynn A, Lin Yinghui, Markgraf Carrie G, Mei Hong, Miller Michael, Poulet Frederique M, Scott Jack D, Smith Michelle D, Yin Zhizhang, Zhou Xiaoping, Parker Eric M, Kennedy Matthew E, Morrow John A, ;2015;The Journal of pharmacology and experimental therapeutics;355;397-409; 26407721
  • GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.;Chen Cang, Li Xiuhua, Ge Guo, Liu Jingwei, Biju K C, Laing Suzette D, Qian Yusheng, Ballard Cori, He Zhixu, Masliah Eliezer, Clark Robert A, O'Connor Jason C, Li Senlin, ;2018;Scientific reports;8;5460; 29615705
  • Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice.;Smith Karen M, Browne Susan E, Jayaraman Srinivasan, Bleickardt Carina J, Hodge Lisa M, Lis Edward, Yao Leon, Rittle Sunday L, Innocent Nathalie, Mullins Deborra E, Boykow George, Reynolds Ian J, Hill David, Parker Eric M, Hodgson Robert A, ;2014;European journal of pharmacology;728;31-8; 24486705
  • Loss of dopamine disrupts circadian rhythms in a mouse model of Parkinson's disease.;Fifel Karim, Cooper Howard M, ;2014;Neurobiology of disease;71;359-69; 25171792
  • Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease.;Ay Muhammet, Luo Jie, Langley Monica, Jin Huajun, Anantharam Vellareddy, Kanthasamy Arthi, Kanthasamy Anumantha G, ;2017;Journal of neurochemistry;141;766-782; 28376279
  • Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease.;Li Xiuhua, Redus Laney, Chen Cang, Martinez Paul A, Strong Randy, Li Senlin, O'Connor Jason C, ;2013;PloS one;8;e71341; 23977020
  • Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors.;Chen Yuan-Hao, Hsieh Tsung-Hsun, Kuo Tung-Tai, Kao Jen-Hsin, Ma Kuo-Hsing, Huang Eagle Yi-Kung, Chou Yu-Ching, Olson Lars, Hoffer Barry J, ;2019;Journal of neurochemistry;150;56-73; 30933310
  • Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.;Langley Monica, Ghosh Anamitra, Charli Adhithiya, Sarkar Souvarish, Ay Muhammet, Luo Jie, Zielonka Jacek, Brenza Timothy, Bennett Brian, Jin Huajun, Ghaisas Shivani, Schlichtmann Benjamin, Kim Dongsuk, Anantharam Vellareddy, Kanthasamy Arthi, Narasimhan Balaji, Kalyanaraman Balaraman, Kanthasamy Anumantha G, ;2017;Antioxidants & redox signaling;27;1048-1066; 28375739
  • Altered glutamate release in the dorsal striatum of the MitoPark mouse model of Parkinson's disease.;Farrand Ariana Q, Gregory Rebecca A, Bäckman Cristina M, Helke Kristi L, Boger Heather A, ;2016;Brain research;1651;88-94; 27659966
  • Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease.;Branch Sarah Y, Chen Cang, Sharma Ramaswamy, Lechleiter James D, Li Senlin, Beckstead Michael J, ;2016;The Journal of neuroscience : the official journal of the Society for Neuroscience;36;4026-37; 27053209
  • PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice.;Zhang YaJun, Granholm Ann-Charlotte, Huh Kyounghee, Shan Lufei, Diaz-Ruiz Oscar, Malik Nasir, Olson Lars, Hoffer Barry J, Lupica Carl R, Hoffman Alexander F, Bäckman Cristina M, ;2012;Brain : a journal of neurology;135;2736-49; 22961549
  • Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice.;Chen Yuan-Hao, Wang Vicki, Huang Eagle Yi-Kung, Chou Yu-Ching, Kuo Tung-Tai, Olson Lars, Hoffer Barry J, ;2019;International journal of molecular sciences;20;261-9; 31835787
  • L-Dopa induced dyskinesias in Parkinsonian mice: Disease severity or L-Dopa history.;Shan Lufei, Diaz Oscar, Zhang Yajun, Ladenheim Bruce, Cadet Jean-Lud, Chiang Yung-Hsiao, Olson Lars, Hoffer Barry J, Bäckman Cristina M, ;2015;Brain research;1618;146301; 26086365
  • Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson's disease.;Lai Jing-Huei, Chen Kai-Yun, Wu John Chung-Che, Olson Lars, Brené Stefan, Huang Chi-Zong, Chen Yen-Hua, Kang Shuo-Jhen, Ma Kuo-Hsing, Hoffer Barry J, Hsieh Tsung-Hsun, Chiang Yung-Hsiao, ;2019;Brain research;1720;12937-42; 31226324
  • Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo.;Sterky Fredrik H, Lee Seungmin, Wibom Rolf, Olson Lars, Larsson Nils-Göran, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;e0151884; 21768369
  • Multimodal MRI Evaluation of the MitoPark Mouse Model of Parkinson's Disease.;Cong Linlin, Muir Eric R, Chen Cang, Qian Yusheng, Liu Jingwei, Biju K C, Clark Robert A, Li Senlin, Duong Timothy Q, ;2016;PloS one;11;442; 27003179
  • Chronic L-DOPA induces hyperactivity, normalization of gait and dyskinetic behavior in MitoPark mice;Additional info;2015;Genes, brain, and behavior;14;4827-35; 26088285
  • Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.;Hong Chien-Tai, Chen Kai-Yun, Wang Weu, Chiu Jing-Yuan, Wu Dean, Chao Tsu-Yi, Hu Chaur-Jong, Chau Kai-Yin David, Bamodu Oluwaseun Adebayo, ;2020;Cells;9;445-454; 32192190
  • Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.;Lee Seungmin, Sterky Fredrik H, Mourier Arnaud, Terzioglu Mügen, Cullheim Staffan, Olson Lars, Larsson Nils-Göran, ;2012;Human molecular genetics;21;12932; 22914740
  • Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson's and Alzheimer's disease.;Gellhaar Sandra, Sunnemark Dan, Eriksson Håkan, Olson Lars, Galter Dagmar, ;2017;Cell and tissue research;369;240-255; 28466093
  • Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry.;Papathanou Maria, Dumas Sylvie, Pettersson Hanna, Olson Lars, Wallén-Mackenzie Åsa, ;2019;eNeuro;6;3646-3657; 31481399
  • Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.;Gordon Richard, Neal Matthew L, Luo Jie, Langley Monica R, Harischandra Dilshan S, Panicker Nikhil, Charli Adhithiya, Jin Huajun, Anantharam Vellareddy, Woodruff Trent M, Zhou Qun-Yong, Kanthasamy Anumantha G, Kanthasamy Arthi, ;2016;Nature communications;7;; 27703142
  • Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity.;Langley Monica R, Ghaisas Shivani, Ay Muhammet, Luo Jie, Palanisamy Bharathi N, Jin Huajun, Anantharam Vellareddy, Kanthasamy Arthi, Kanthasamy Anumantha G, ;2018;Neurotoxicology;64;; 28595911
  • Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson's Disease.;Hsieh Tsung-Hsun, Kuo Chi-Wei, Hsieh Kai-Hsuan, Shieh Meng-Jyh, Peng Chih-Wei, Chen Yen-Chien, Chang Ying-Ling, Huang Ying-Zu, Chen Chih-Chung, Chang Pi-Kai, Chen Kai-Yun, Chen Hsin-Yung, ;2020;Brain sciences;10;; 32244769
  • The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection.;Paß Thomas, Aßfalg Marlene, Tolve Marianna, Blaess Sandra, Rothermel Markus, Wiesner Rudolf J, Ricke Konrad M, ;2020;Molecular neurobiology;57;; 32564285
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal tooth morphology / IMPC
  • hyperactivity / IMPC
  • increased circulating sodium level / IMPC
  • absent teeth / IMPC
  • increased heart weight / IMPC
  • decreased circulating free fatty acids level / IMPC
MGI phenotypes (gene matching)
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal maternal nurturing / MGI
  • hyperactivity / MGI
  • impaired coordination / MGI
  • short stride length / MGI
  • increased stereotypic behavior / MGI
  • increased exploration in new environment / MGI
  • abnormal grooming behavior / MGI
  • abnormal spatial learning / MGI
  • postnatal growth retardation / MGI
  • abnormal pituitary secretion / MGI
  • increased dopamine level / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • abnormal CNS synaptic transmission / MGI
  • disproportionate dwarf / MGI
  • increased vertical activity / MGI
  • decreased vertical activity / MGI
  • increased thigmotaxis / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • enhanced long term potentiation / MGI
  • abnormal dopaminergic neuron morphology / MGI
  • loss of dopaminergic neurons / MGI
  • abnormal locomotor activation / MGI
  • hypopituitarism / MGI
  • abnormal neurotransmitter uptake / MGI
  • abnormal response to novel object / MGI
  • abnormal response to novel odor / MGI
  • nervous system phenotype / MGI
  • decreased neurotransmitter release / MGI
  • abnormal adenohypophysis morphology / MGI
  • decreased length of long bones / MGI
  • abnormal neuron physiology / MGI
  • abnormal behavior / MGI
  • small pituitary gland / MGI
  • growth/size/body region phenotype / MGI
  • behavior/neurological phenotype / MGI
  • reproductive system phenotype / MGI
  • taste/olfaction phenotype / MGI
  • abnormal action potential / MGI
  • decreased dopamine level / MGI
  • abnormal pituitary gland physiology / MGI
  • decreased somatotroph cell number / MGI
  • decreased lactotroph cell number / MGI
  • adenohypophysis hypoplasia / MGI
  • pituitary intermediate lobe hypoplasia / MGI
  • abnormal physiological response to xenobiotic / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • abnormal miniature inhibitory postsynaptic currents / MGI
  • impaired conditioned place preference behavior / MGI
  • abnormal behavioral response to xenobiotic / MGI
  • increased serotonin level / MGI
  • abnormal synaptic dopamine release / MGI
  • lactation failure / MGI
  • mortality/aging / MGI
  • lethality, incomplete penetrance / MGI
  • decreased dopaminergic neuron number / MGI
  • decreased susceptibility to dopaminergic neuron neurotoxicity / MGI

Literature references

  • VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation.;Birgner Carolina, Nordenankar Karin, Lundblad Martin, Mendez José Alfredo, Smith Casey, le Grevès Madeleine, Galter Dagmar, Olson Lars, Fredriksson Anders, Trudeau Louis-Eric, Kullander Klas, Wallén-Mackenzie Asa, ;2010;Proceedings of the National Academy of Sciences of the United States of America;107;389-94; 20018672
  • Enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of VGLUT2 in midbrain dopamine neurons in mice.;Alsiö Johan, Nordenankar Karin, Arvidsson Emma, Birgner Carolina, Mahmoudi Souha, Halbout Briac, Smith Casey, Fortin Guillaume M, Olson Lars, Descarries Laurent, Trudeau Louis-Éric, Kullander Klas, Lévesque Daniel, Wallén-Mackenzie Asa, ;2011;The Journal of neuroscience : the official journal of the Society for Neuroscience;31;12593-603; 21880920
  • Mitochondrial Dysfunction Combined with High Calcium Load Leads to Impaired Antioxidant Defense Underlying the Selective Loss of Nigral Dopaminergic Neurons.;Ricke Konrad M, Paß Thomas, Kimoloi Sammy, Fährmann Kai, Jüngst Christian, Schauss Astrid, Baris Olivier R, Aradjanski Marijana, Trifunovic Aleksandra, Eriksson Faelker Therese M, Bergami Matteo, Wiesner Rudolf J, ;2020;The Journal of neuroscience : the official journal of the Society for Neuroscience;40;1975-1986; 32005765
  • Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction.;Kao Chung-Yang, Xu Mafei, Wang Leiming, Lin Shih-Chieh, Lee Hui-Ju, Duraine Lita, Bellen Hugo J, Goldstein David S, Tsai Sophia Y, Tsai Ming-Jer, ;2020;PLoS genetics;16;e1008868; 32579581
  • MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson's disease.;Ghaisas Shivani, Langley Monica R, Palanisamy Bharathi N, Dutta Somak, Narayanaswamy Kirthi, Plummer Paul J, Sarkar Souvarish, Ay Muhammet, Jin Huajun, Anantharam Vellareddy, Kanthasamy Arthi, Kanthasamy Anumantha G, ;2019;Neurotoxicology;75;186-199; 31505196
  • Cerebrospinal fluid neurofilament light chain as a biomarker of neurodegeneration in the Tg4510 and MitoPark mouse models.;Clement Amalie, Mitchelmore Cathy, Andersson Daniel R, Asuni Ayodeji A, ;2017;Neuroscience;354;101-109; 28461218
  • Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson's Disease.;Chen Cang, Guderyon Michael J, Li Yang, Ge Guo, Bhattacharjee Anindita, Ballard Cori, He Zhixu, Masliah Eliezer, Clark Robert A, O'Connor Jason C, Li Senlin, ;2020;Molecular therapy. Methods & clinical development;17;83-98; 31890743
  • Chronic A2A antagonist treatment alleviates parkinsonian locomotor deficiency in MitoPark mice.;Marcellino Daniel, Lindqvist Eva, Schneider Marion, Müller Christa E, Fuxe Kjell, Olson Lars, Galter Dagmar, ;2010;Neurobiology of disease;40;460-6; 20656029
  • Progressively disrupted somatodendritic morphology in dopamine neurons in a mouse Parkinson's model.;Lynch William B, Tschumi Christopher W, Sharpe Amanda L, Branch Sarah Y, Chen Cang, Ge Guo, Li Senlin, Beckstead Michael J, ;2018;Movement disorders : official journal of the Movement Disorder Society;33;1928-1937; 30440089
  • MitoPark mice, an animal model of Parkinson's disease, show enhanced prepulse inhibition of acoustic startle and no loss of gating in response to the adenosine A(2A) antagonist SCH 412348.;Grauer Steven M, Hodgson Robert, Hyde Lynn A, ;2014;Psychopharmacology;231;1325-37; 24150248
  • A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease.;Le Poul Emmanuel, Boléa Christelle, Girard Francoise, Poli Sonia, Charvin Delphine, Campo Brice, Bortoli Julien, Bessif Abdhelak, Luo Bin, Koser Amy Jo, Hodge Lisa M, Smith Karen M, DiLella Anthony G, Liverton Nigel, Hess Fred, Browne Susan E, Reynolds Ian J, ;2012;The Journal of pharmacology and experimental therapeutics;343;167-77; 22787118
  • Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.;Westerlund Marie, Ran Caroline, Borgkvist Anders, Sterky Fredrik H, Lindqvist Eva, Lundströmer Karin, Pernold Karin, Brené Stefan, Kallunki Pekka, Fisone Gilberto, Olson Lars, Galter Dagmar, ;2008;Molecular and cellular neurosciences;39;586-91; 18790059
  • Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease.;Good Cameron H, Hoffman Alexander F, Hoffer Barry J, Chefer Vladimir I, Shippenberg Toni S, Bäckman Cristina M, Larsson Nils-Göran, Olson Lars, Gellhaar Sandra, Galter Dagmar, Lupica Carl R, ;2011;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;25;1333-44; 21233488
  • Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons.;Ekstrand Mats I, Terzioglu Mügen, Galter Dagmar, Zhu Shunwei, Hofstetter Christoph, Lindqvist Eva, Thams Sebastian, Bergstrand Anita, Hansson Fredrik Sterky, Trifunovic Aleksandra, Hoffer Barry, Cullheim Staffan, Mohammed Abdul H, Olson Lars, Larsson Nils-Göran, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;1325-30; 17227870
  • MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease.;Galter D, Pernold K, Yoshitake T, Lindqvist E, Hoffer B, Kehr J, Larsson N-G, Olson L, ;2010;Genes, brain, and behavior;9;173-81; 20002202
  • Chronic L-DOPA induces hyperactivity, normalization of gait and dyskinetic behavior in MitoPark mice.;Gellhaar S, Marcellino D, Abrams M B, Galter D, ;2015;Genes, brain, and behavior;14;260-70; 25752644
  • MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.;Fell Matthew J, Mirescu Christian, Basu Kallol, Cheewatrakoolpong Boonlert, DeMong Duane E, Ellis J Michael, Hyde Lynn A, Lin Yinghui, Markgraf Carrie G, Mei Hong, Miller Michael, Poulet Frederique M, Scott Jack D, Smith Michelle D, Yin Zhizhang, Zhou Xiaoping, Parker Eric M, Kennedy Matthew E, Morrow John A, ;2015;The Journal of pharmacology and experimental therapeutics;355;397-409; 26407721
  • GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.;Chen Cang, Li Xiuhua, Ge Guo, Liu Jingwei, Biju K C, Laing Suzette D, Qian Yusheng, Ballard Cori, He Zhixu, Masliah Eliezer, Clark Robert A, O'Connor Jason C, Li Senlin, ;2018;Scientific reports;8;5460; 29615705
  • Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice.;Smith Karen M, Browne Susan E, Jayaraman Srinivasan, Bleickardt Carina J, Hodge Lisa M, Lis Edward, Yao Leon, Rittle Sunday L, Innocent Nathalie, Mullins Deborra E, Boykow George, Reynolds Ian J, Hill David, Parker Eric M, Hodgson Robert A, ;2014;European journal of pharmacology;728;31-8; 24486705
  • Loss of dopamine disrupts circadian rhythms in a mouse model of Parkinson's disease.;Fifel Karim, Cooper Howard M, ;2014;Neurobiology of disease;71;359-69; 25171792
  • Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease.;Ay Muhammet, Luo Jie, Langley Monica, Jin Huajun, Anantharam Vellareddy, Kanthasamy Arthi, Kanthasamy Anumantha G, ;2017;Journal of neurochemistry;141;766-782; 28376279
  • Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease.;Li Xiuhua, Redus Laney, Chen Cang, Martinez Paul A, Strong Randy, Li Senlin, O'Connor Jason C, ;2013;PloS one;8;e71341; 23977020
  • Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors.;Chen Yuan-Hao, Hsieh Tsung-Hsun, Kuo Tung-Tai, Kao Jen-Hsin, Ma Kuo-Hsing, Huang Eagle Yi-Kung, Chou Yu-Ching, Olson Lars, Hoffer Barry J, ;2019;Journal of neurochemistry;150;56-73; 30933310
  • Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.;Langley Monica, Ghosh Anamitra, Charli Adhithiya, Sarkar Souvarish, Ay Muhammet, Luo Jie, Zielonka Jacek, Brenza Timothy, Bennett Brian, Jin Huajun, Ghaisas Shivani, Schlichtmann Benjamin, Kim Dongsuk, Anantharam Vellareddy, Kanthasamy Arthi, Narasimhan Balaji, Kalyanaraman Balaraman, Kanthasamy Anumantha G, ;2017;Antioxidants & redox signaling;27;1048-1066; 28375739
  • Altered glutamate release in the dorsal striatum of the MitoPark mouse model of Parkinson's disease.;Farrand Ariana Q, Gregory Rebecca A, Bäckman Cristina M, Helke Kristi L, Boger Heather A, ;2016;Brain research;1651;88-94; 27659966
  • Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease.;Branch Sarah Y, Chen Cang, Sharma Ramaswamy, Lechleiter James D, Li Senlin, Beckstead Michael J, ;2016;The Journal of neuroscience : the official journal of the Society for Neuroscience;36;4026-37; 27053209
  • PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice.;Zhang YaJun, Granholm Ann-Charlotte, Huh Kyounghee, Shan Lufei, Diaz-Ruiz Oscar, Malik Nasir, Olson Lars, Hoffer Barry J, Lupica Carl R, Hoffman Alexander F, Bäckman Cristina M, ;2012;Brain : a journal of neurology;135;2736-49; 22961549
  • Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice.;Chen Yuan-Hao, Wang Vicki, Huang Eagle Yi-Kung, Chou Yu-Ching, Kuo Tung-Tai, Olson Lars, Hoffer Barry J, ;2019;International journal of molecular sciences;20;261-9; 31835787
  • L-Dopa induced dyskinesias in Parkinsonian mice: Disease severity or L-Dopa history.;Shan Lufei, Diaz Oscar, Zhang Yajun, Ladenheim Bruce, Cadet Jean-Lud, Chiang Yung-Hsiao, Olson Lars, Hoffer Barry J, Bäckman Cristina M, ;2015;Brain research;1618;146301; 26086365
  • Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson's disease.;Lai Jing-Huei, Chen Kai-Yun, Wu John Chung-Che, Olson Lars, Brené Stefan, Huang Chi-Zong, Chen Yen-Hua, Kang Shuo-Jhen, Ma Kuo-Hsing, Hoffer Barry J, Hsieh Tsung-Hsun, Chiang Yung-Hsiao, ;2019;Brain research;1720;12937-42; 31226324
  • Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo.;Sterky Fredrik H, Lee Seungmin, Wibom Rolf, Olson Lars, Larsson Nils-Göran, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;e0151884; 21768369
  • Multimodal MRI Evaluation of the MitoPark Mouse Model of Parkinson's Disease.;Cong Linlin, Muir Eric R, Chen Cang, Qian Yusheng, Liu Jingwei, Biju K C, Clark Robert A, Li Senlin, Duong Timothy Q, ;2016;PloS one;11;442; 27003179
  • Chronic L-DOPA induces hyperactivity, normalization of gait and dyskinetic behavior in MitoPark mice;Additional info;2015;Genes, brain, and behavior;14;4827-35; 26088285
  • Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.;Hong Chien-Tai, Chen Kai-Yun, Wang Weu, Chiu Jing-Yuan, Wu Dean, Chao Tsu-Yi, Hu Chaur-Jong, Chau Kai-Yin David, Bamodu Oluwaseun Adebayo, ;2020;Cells;9;445-454; 32192190
  • Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.;Lee Seungmin, Sterky Fredrik H, Mourier Arnaud, Terzioglu Mügen, Cullheim Staffan, Olson Lars, Larsson Nils-Göran, ;2012;Human molecular genetics;21;12932; 22914740
  • Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson's and Alzheimer's disease.;Gellhaar Sandra, Sunnemark Dan, Eriksson Håkan, Olson Lars, Galter Dagmar, ;2017;Cell and tissue research;369;240-255; 28466093
  • Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry.;Papathanou Maria, Dumas Sylvie, Pettersson Hanna, Olson Lars, Wallén-Mackenzie Åsa, ;2019;eNeuro;6;3646-3657; 31481399
  • Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.;Gordon Richard, Neal Matthew L, Luo Jie, Langley Monica R, Harischandra Dilshan S, Panicker Nikhil, Charli Adhithiya, Jin Huajun, Anantharam Vellareddy, Woodruff Trent M, Zhou Qun-Yong, Kanthasamy Anumantha G, Kanthasamy Arthi, ;2016;Nature communications;7;; 27703142
  • Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity.;Langley Monica R, Ghaisas Shivani, Ay Muhammet, Luo Jie, Palanisamy Bharathi N, Jin Huajun, Anantharam Vellareddy, Kanthasamy Arthi, Kanthasamy Anumantha G, ;2018;Neurotoxicology;64;; 28595911
  • Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson's Disease.;Hsieh Tsung-Hsun, Kuo Chi-Wei, Hsieh Kai-Hsuan, Shieh Meng-Jyh, Peng Chih-Wei, Chen Yen-Chien, Chang Ying-Ling, Huang Ying-Zu, Chen Chih-Chung, Chang Pi-Kai, Chen Kai-Yun, Chen Hsin-Yung, ;2020;Brain sciences;10;; 32244769
  • The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection.;Paß Thomas, Aßfalg Marlene, Tolve Marianna, Blaess Sandra, Rothermel Markus, Wiesner Rudolf J, Ricke Konrad M, ;2020;Molecular neurobiology;57;; 32564285

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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