B6;CBA-Tg(Cyp11a1-icre)1Aswn/H
| Status | Available to order |
| EMMA ID | EM:13204 |
| International strain name | B6;CBA-Tg(Cyp11a1-icre)1Aswn/H |
| Alternative name | Cyp11a1-iCre (BAC49) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Cyp11a1-icre)1Aswn |
| Gene/Transgene symbol | Tg(Cyp11a1-icre)1Aswn |
Information from provider
| Provider | Amanda Swain |
| Provider affiliation | Institute of Cancer Research |
| Genetic information | Mouse BAC transgene containing CYP11a1 locus with icre, plus rabbit beta globin polyadenylation signal inserted 14bp upstream of Cyp11a1 ATG codon. |
| Phenotypic information | Homozygous:We have not observed a homozygous phenotype, although we have not analysed many animals with this genotype.Heterozygous:Heterozygous and homozygous transgenic animals are normal. |
| Breeding history | Crossed to either non transgenic littermates or C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.;Francis Jeffrey C, Gardiner Jennifer R, Renaud Yoan, Chauhan Ritika, Weinstein Yacob, Gomez-Sanchez Celso, Lefrançois-Martinez Anne-Marie, Bertherat Jérôme, Val Pierre, Swain Amanda, ;2021;British journal of cancer;124;805-816; 33214683
- In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.;Buaas F William, Gardiner Jennifer R, Clayton Sally, Val Pierre, Swain Amanda, ;2012;Development (Cambridge, England);139;4561-70; 23136395