B6;CBA-Tg(Cyp11a1-icre)1Aswn/H

Status	Available to order
EMMA ID	EM:13204
Citation information	RRID:IMSR_EM:13204 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;CBA-Tg(Cyp11a1-icre)1Aswn/H
Alternative name	Cyp11a1-iCre (BAC49)
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Cyp11a1-icre)1Aswn
Gene/Transgene symbol	Tg(Cyp11a1-icre)1Aswn

Information from provider

Provider	Amanda Swain
Provider affiliation	Institute of Cancer Research
Genetic information	Mouse BAC transgene containing CYP11a1 locus with icre, plus rabbit beta globin polyadenylation signal inserted 14bp upstream of Cyp11a1 ATG codon.
Phenotypic information	Homozygous: We have not observed a homozygous phenotype, although we have not analysed many animals with this genotype. Heterozygous: Heterozygous and homozygous transgenic animals are normal.
Breeding history	Crossed to either non transgenic littermates or C57BL/6.
References	HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.;Francis Jeffrey C, Gardiner Jennifer R, Renaud Yoan, Chauhan Ritika, Weinstein Yacob, Gomez-Sanchez Celso, Lefrançois-Martinez Anne-Marie, Bertherat Jérôme, Val Pierre, Swain Amanda, ;2021;British journal of cancer;124;805-816; 33214683 In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.;Buaas F William, Gardiner Jennifer R, Clayton Sally, Val Pierre, Swain Amanda, ;2012;Development (Cambridge, England);139;4561-70; 23136395
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.;Francis Jeffrey C, Gardiner Jennifer R, Renaud Yoan, Chauhan Ritika, Weinstein Yacob, Gomez-Sanchez Celso, Lefrançois-Martinez Anne-Marie, Bertherat Jérôme, Val Pierre, Swain Amanda, ;2021;British journal of cancer;124;805-816; 33214683
In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.;Buaas F William, Gardiner Jennifer R, Clayton Sally, Val Pierre, Swain Amanda, ;2012;Development (Cambridge, England);139;4561-70; 23136395

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