IMPC phenotypes (gene matching)
C3HeB/FeJ-Krt71Mhdarco12/Ieg
| Status | Available to order |
| EMMA ID | EM:01318 |
| International strain name | C3HeB/FeJ-Krt71Mhdarco12/Ieg |
| Alternative name | RCO012 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Krt71Mhdarco12 |
| Gene/Transgene symbol | Krt71 |
Information from provider
| Provider | Martin Hrabe de Angelis |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | Hair: hair texture defects, extremities: digit dysmorphology. |
| Phenotypic information | Hair: hair texture defects, extremities: digit dysmorphology. |
| Breeding history | More than 2 times backcrossed on C3HeB/FeJ. |
| References |
|
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Woolly hair / Orphanet_170
MGI phenotypes (gene matching)
- abnormal hair follicle morphology / MGI
- waved hair / MGI
- alopecia / MGI
- focal hair loss / MGI
- curly vibrissae / MGI
- abnormal coat appearance / MGI
- abnormal vibrissa morphology / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair cortex morphology / MGI
- hearing/vestibular/ear phenotype / MGI
- vision/eye phenotype / MGI
- whorled hair / MGI
- focal dorsal hair loss / MGI
- abnormal hair follicle inner root sheath morphology / MGI
Literature references
- Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192
- Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017
- Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71rco12 and Krt71rco13.;Runkel Fabian, Klaften Matthias, Koch Kerstin, Böhnert Volker, Büssow Heinrich, Fuchs Helmut, Franz Thomas, Hrabé de Angelis Martin, ;2006;Mammalian genome : official journal of the International Mammalian Genome Society;17;1172-82; 17143583