C3HeB/FeJ-Hoxaas2m1Mhda/Ieg
| Status | Available to order |
| EMMA ID | EM:13161 |
| International strain name | C3HeB/FeJ-Hoxaas2m1Mhda/Ieg |
| Alternative name | Hoxaas2 Mut Glu99Gly |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Hoxaas2m1Mhda |
| Gene/Transgene symbol | Hoxaas2 |
Information from provider
| Provider | Martin Hrabé de Angelis |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Center Munich |
| Genetic information | ENU derived mouse with an Hoxaas2 point mutation Glu99Gly (296A->G).
The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt. Disclaimer - Special restrictions: 1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols. 2) Some lines showed low penetrance of the phenotype. 3) Only sperm available. Rederivation service can not be offered. 4) EMMA quality control standards may not apply for these strains. 5) EMMA has not verified the breeding performance and the genetic background of the strains. The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt. |
| Phenotypic information | Homozygous:Animals with a hetero- and homozygous Hoxaas2 mutation present a phenotype of mild hyperaldosteronism (increased baseline aldosterone values)Heterozygous:Animals with a hetero- and homozygous Hoxaas2 mutation present a phenotype of mild hyperaldosteronism (increased baseline aldosterone values) |
| Breeding history | Upon embryo transfer of the EMMA deposited mouse line ADH004 (carrying at least 4 point mutations) by Dr. S. Marschall, further breeding lead to the segregation of these four mutations and to the breeding of a mouse line with a heterozygous Hoxaas2 Glu99Gly mutation. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous C3HeB/FeJ |
Literature references
- Genetic characterization of a mouse line with primary aldosteronism.;Perez-Rivas L G, Rhayem Y, Sabrautzki S, Hantel C, Rathkolb B, Hrabě de Angelis M, Reincke M, Beuschlein F, Spyroglou A, ;2017;Journal of molecular endocrinology;58;67-78; 27965370