C57BL/6NTac-Xbp1tm1c(EUCOMM)Wtsi/IcsOrl

Status

Available to order

EMMA IDEM:13138
Citation informationRRID:IMSR_EM:13138 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Xbp1tm1c(EUCOMM)Wtsi/IcsOrl
Alternative nameC57BL/6NTac-Xbp1 tm1c(EUCOMM)Wtsi/IcsOrl
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolXbp1tm1c(EUCOMM)Wtsi
Gene/Transgene symbolXbp1

Information from provider

ProviderCécile FREMOND
Provider affiliationCNRS-TAAM-CDTA-UPS44
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0038_2_E10. For further details on the construction of this clone see the page at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele.
Phenotypic informationHomozygous:
Homozygous mice have not been generated

Heterozygous:
null
Breeding historyRederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased circulating triglyceride level / IMPC
  • abnormal behavior / IMPC
  • decreased T cell number / IMPC
  • thrombocytopenia / IMPC
  • increased grip strength / IMPC
  • increased mean corpuscular volume / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased total body fat amount / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • persistence of hyaloid vascular system / IMPC
  • decreased leukocyte cell number / IMPC
  • cataract / IMPC
  • decreased large unstained cell number / IMPC
  • decreased red blood cell distribution width / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased lean body mass / IMPC
  • abnormal lens morphology / IMPC
  • vertebral fusion / IMPC
  • decreased lymphocyte cell number / IMPC
  • increased bone mineral content / IMPC
  • abnormal bone mineralization / IMPC
  • increased body weight / IMPC
  • abnormal vertebral arch morphology / IMPC
  • abnormal urination / IMPC
MGI phenotypes (gene matching)
  • abnormal heart development / MGI
  • thin ventricular wall / MGI
  • enlarged pericardium / MGI
  • absent trabeculae carneae / MGI
  • decreased cell proliferation / MGI
  • abnormal liver development / MGI
  • liver hypoplasia / MGI
  • small liver / MGI
  • wavy neural tube / MGI
  • anemia / MGI
  • impaired hematopoiesis / MGI
  • abnormal blood vessel morphology / MGI
  • decreased embryo size / MGI
  • anoxia / MGI
  • pallor / MGI
  • increased hepatocyte apoptosis / MGI
  • embryonic growth retardation / MGI
  • decreased hepatocyte proliferation / MGI
  • abnormal extraembryonic tissue physiology / MGI
  • myocardial necrosis / MGI
  • decreased embryo weight / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryo tissue necrosis / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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