C57BL/6NTac-Tnfrsf9tm1c(EUCOMM)Wtsi/IcsOrl

Status

Available to order

EMMA IDEM:13136
International strain nameC57BL/6NTac-Tnfrsf9tm1c(EUCOMM)Wtsi/IcsOrl
Alternative nameC57BL/6NTac-Tnfrsf9 tm1c(EUCOMM)Wtsi/IcsOrl
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolTnfrsf9tm1c(EUCOMM)Wtsi
Gene/Transgene symbolTnfrsf9

Information from provider

ProviderCécile FREMOND
Provider affiliationCNRS-TAAM-CDTA-UPS44
Additional ownerThis mutant was created using EUCOMM's tm1a allele generated from targeted ES cells. Needs to be distributed using the provided MTA
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0177_2_B12. For further details on the construction of this clone see the page at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele.
Phenotypic informationHomozygous:
null

Heterozygous:
null
Breeding historyRederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal glucose homeostasis / MGI
  • abnormal T cell physiology / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgA level / MGI
  • no phenotypic analysis / MGI
  • insulitis / MGI
  • increased B cell number / MGI
  • abnormal cytotoxic T cell physiology / MGI
  • increased T cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal common myeloid progenitor cell morphology / MGI
  • abnormal memory T cell physiology / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • decreased IgG2a level / MGI
  • decreased IgG3 level / MGI
  • increased IgG2a level / MGI
  • increased IgG2b level / MGI
  • decreased interferon-gamma secretion / MGI
  • decreased interleukin-12 secretion / MGI
  • decreased interleukin-2 secretion / MGI
  • decreased interleukin-4 secretion / MGI
  • increased splenocyte proliferation / MGI
  • increased effector memory CD4-positive, alpha-beta T cell number / MGI
  • increased effector memory CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, naive alpha-beta T cell number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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