IMPC phenotypes (gene matching)
- preweaning lethality, incomplete penetrance / IMPC
C57BL/6NTac-Tnfrsf9tm1c(EUCOMM)Wtsi/IcsOrl
| Status | Available to order |
| EMMA ID | EM:13136 |
| Citation information | RRID:IMSR_EM:13136 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Tnfrsf9tm1c(EUCOMM)Wtsi/IcsOrl |
| Alternative name | C57BL/6NTac-Tnfrsf9 tm1c(EUCOMM)Wtsi/IcsOrl |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tnfrsf9tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Tnfrsf9 |
Information from provider
| Provider | Cécile FREMOND |
| Provider affiliation | CNRS-TAAM-CDTA-UPS44 |
| Additional owner | This mutant was created using EUCOMM's tm1a allele generated from targeted ES cells. Needs to be distributed using the provided MTA |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0177_2_B12. For further details on the construction of this clone see the page at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele. |
| Phenotypic information | Homozygous:nullHeterozygous:null |
| Breeding history | Rederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6NTac males |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal glucose homeostasis / MGI
- abnormal T cell physiology / MGI
- abnormal immunoglobulin level / MGI
- increased IgA level / MGI
- no phenotypic analysis / MGI
- insulitis / MGI
- increased B cell number / MGI
- abnormal cytotoxic T cell physiology / MGI
- increased T cell proliferation / MGI
- immune system phenotype / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- abnormal memory T cell physiology / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased single-positive T cell number / MGI
- decreased IgG2a level / MGI
- decreased IgG3 level / MGI
- increased IgG2a level / MGI
- increased IgG2b level / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-12 secretion / MGI
- decreased interleukin-2 secretion / MGI
- decreased interleukin-4 secretion / MGI
- increased splenocyte proliferation / MGI
- increased effector memory CD4-positive, alpha-beta T cell number / MGI
- increased effector memory CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, naive alpha-beta T cell number / MGI