IMPC phenotypes (gene matching)
- preweaning lethality, incomplete penetrance / IMPC
C57BL/6NTac-Tnfrsf9tm1c(EUCOMM)Wtsi/IcsOrl
| Status | Available to order |
| EMMA ID | EM:13136 |
| International strain name | C57BL/6NTac-Tnfrsf9tm1c(EUCOMM)Wtsi/IcsOrl |
| Alternative name | C57BL/6NTac-Tnfrsf9 tm1c(EUCOMM)Wtsi/IcsOrl |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tnfrsf9tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Tnfrsf9 |
Information from provider
| Provider | Cécile FREMOND |
| Provider affiliation | CNRS-TAAM-CDTA-UPS44 |
| Additional owner | This mutant was created using EUCOMM's tm1a allele generated from targeted ES cells. Needs to be distributed using the provided MTA |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0177_2_B12. For further details on the construction of this clone see the page at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele. |
| Phenotypic information | Homozygous:nullHeterozygous:null |
| Breeding history | Rederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6NTac |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal glucose homeostasis / MGI
- abnormal T cell physiology / MGI
- abnormal immunoglobulin level / MGI
- increased IgA level / MGI
- no phenotypic analysis / MGI
- insulitis / MGI
- increased B cell number / MGI
- abnormal cytotoxic T cell physiology / MGI
- increased T cell proliferation / MGI
- immune system phenotype / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- abnormal memory T cell physiology / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased single-positive T cell number / MGI
- decreased IgG2a level / MGI
- decreased IgG3 level / MGI
- increased IgG2a level / MGI
- increased IgG2b level / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-12 secretion / MGI
- decreased interleukin-2 secretion / MGI
- decreased interleukin-4 secretion / MGI
- increased splenocyte proliferation / MGI
- increased effector memory CD4-positive, alpha-beta T cell number / MGI
- increased effector memory CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, naive alpha-beta T cell number / MGI