B6NCrl;B6N-Atm1Brd Sall3tm1(KOMP)Mbp/Ph

Status

Under development - register interest

EMMA IDEM:13100
Citation informationRRID:IMSR_EM:13100 

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International strain nameB6NCrl;B6N-Atm1Brd Sall3tm1(KOMP)Mbp/Ph
Alternative nameDEPD00578_5_A12
Strain type
Allele/Transgene symbolSall3tm1(KOMP)Mbp
Gene/Transgene symbolSall3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from KOMP ES clone DEPD00578_5_A12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal thymus morphology / IMPC
  • abnormal lymph node morphology / IMPC
  • abnormal testis morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • enlarged thymus / IMPC
  • enlarged heart / IMPC
  • enlarged testis / IMPC
  • small testis / IMPC
  • increased cardiac muscle contractility / IMPC
  • abnormal skin morphology / IMPC
  • abnormal uterus morphology / IMPC
  • abnormal caudal vertebrae morphology / IMPC
  • abnormal heart morphology / IMPC
  • hyperactivity / IMPC
  • enlarged lymph nodes / IMPC

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Register interest

Availabilities

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    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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    Legally binding conditions for the transfer

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