B6.Cg-Sox6tm1.1(cre/ERT)Lpm/LpmH
| Status | Available to order |
| EMMA ID | EM:13090 |
| International strain name | B6.Cg-Sox6tm1.1(cre/ERT)Lpm/LpmH |
| Alternative name | Sox6GFPCreERT |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Sox6tm1GFPCreERT |
| Gene/Transgene symbol | Sox6 |
Information from provider
| Provider | Lia Panman |
| Provider affiliation | MRC Toxicology Unit, University of Cambridge |
| Genetic information | In frame insertion of GFP-creERT in exon 8 (first coding exon of Sox6), which was achieved by homologous recombination in ES cells. The insertion resulted in disruption of Sox6 gene function. |
| Phenotypic information | Homozygous:Homozygous mice die immediately after birth. Homozygous embryos have defects in cortical development, oligodendrocyte maturation, cartilage development and skeletal muscle differentiation.Heterozygous:Heterozygous or hemizygous animals do not display any obvious phenotype. |
| Breeding history | Neo cassette was removed by breeding the animals with Flp recombinase deleter mice. Subsequently the colony was maintained by crossing heterozygous animals to C57BL/6J animals. The colony was backcrossed for at least 12 generations. |
| References | None available |
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |