B6.Cg-Sox6tm1.1(cre/ERT)Lpm/LpmH
| Status | Available to order |
| EMMA ID | EM:13090 |
| Citation information | RRID:IMSR_EM:13090 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Sox6tm1.1(cre/ERT)Lpm/LpmH |
| Alternative name | Sox6GFPCreERT |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Sox6tm1GFPCreERT |
| Gene/Transgene symbol | Sox6 |
Information from provider
| Provider | Lia Panman |
| Provider affiliation | MRC Toxicology Unit, University of Cambridge |
| Genetic information | In frame insertion of GFP-creERT in exon 8 (first coding exon of Sox6), which was achieved by homologous recombination in ES cells. The insertion resulted in disruption of Sox6 gene function. |
| Phenotypic information | Homozygous:Homozygous mice die immediately after birth. Homozygous embryos have defects in cortical development, oligodendrocyte maturation, cartilage development and skeletal muscle differentiation.Heterozygous:Heterozygous or hemizygous animals do not display any obvious phenotype. |
| Breeding history | Neo cassette was removed by breeding the animals with Flp recombinase deleter mice. Subsequently the colony was maintained by crossing heterozygous animals to C57BL/6J animals. The colony was backcrossed for at least 12 generations. |
| References | None available |
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |