IMPC phenotypes (gene matching)
B6.Cg-Trp73tm1Gml/H
| Status | Available to order |
| EMMA ID | EM:13067 |
| International strain name | B6.Cg-Trp73tm1Gml/H |
| Alternative name | Trp73fl/fl (Trp73 flox/flox) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Trp73tm1Gml |
| Gene/Transgene symbol | Trp73 |
Information from provider
| Provider | Gerry Melino |
| Provider affiliation | MRC Toxicology Unit |
| Genetic information | This is the floxed strain used for the generation of Trp73D13/D13 strain (EMMA strain EM:13068). Floxed (Trp73fl/fl) mice were obtained by introducing a vector containing loxP sites flanking exon 13 of the Trp73 gene, which was replaced by a neoR cassette to enable selection. Immediately upstream and downstream of these sites, long terminal repeats (LTRs) facilitated incorporation of the vector into ES cells by homologous recombination. |
| Phenotypic information | Homozygous:No abnormalitiesHeterozygous:No abnormalities |
| Breeding history | Backcrossed more than 10 generations |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- absent Cajal-Retzius cell / MGI
- domed cranium / MGI
- gastrointestinal hemorrhage / MGI
- absent enterocytes / MGI
- excessive digestive secretion / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal cortical marginal zone morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal hippocampus development / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal choroid plexus morphology / MGI
- dilated lateral ventricles / MGI
- abnormal hypothalamus morphology / MGI
- abnormal trigeminal ganglion morphology / MGI
- decreased body size / MGI
- submission towards male mice / MGI
- reduced male mating frequency / MGI
- abnormal embryo development / MGI
- periorbital edema / MGI
- increased susceptibility to otitis media / MGI
- conjunctivitis / MGI
- rhinitis / MGI
- sinus inflammation / MGI
- hydroencephaly / MGI
- non-obstructive hydrocephaly / MGI
- abnormal cerebrospinal fluid production / MGI
- intracranial hemorrhage / MGI
- intraventricular hemorrhage / MGI
- reduced fertility / MGI
- male infertility / MGI
- female infertility / MGI
- abnormal ovulation / MGI
- neoplasm / MGI
- increased cellular sensitivity to gamma-irradiation / MGI
- increased malignant tumor incidence / MGI
- increased tumor incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- increased lung adenocarcinoma incidence / MGI
- increased carcinoma incidence / MGI
- increased lung adenoma incidence / MGI
- premature death / MGI
- neurodegeneration / MGI
- abnormal vomeronasal organ morphology / MGI
- increased susceptibility to bacterial infection / MGI
- chronic inflammation / MGI
- abnormal hippocampal mossy fiber morphology / MGI
- abnormal cell cycle / MGI
- increased neuron apoptosis / MGI
- abnormal forebrain development / MGI
- increased hemangiosarcoma incidence / MGI
- maternal effect / MGI
- abnormal chromosome number / MGI
- polyploidy / MGI
- increased incidence of tumors by chemical induction / MGI
- cachexia / MGI
- abnormal female meiosis / MGI
- decreased oocyte number / MGI
- decreased Cajal-Retzius cell number / MGI
- abnormal dendrite morphology / MGI
- abnormal hippocampus CA3 region morphology / MGI
- anovulation / MGI
- abnormal ovarian follicle number / MGI
- increased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced cell death / MGI
- decreased neuron number / MGI
- distended ileum / MGI
- increased thymocyte apoptosis / MGI
- abnormal meiotic spindle morphology / MGI
- abnormal hippocampus neuron morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- increased lymphoma incidence / MGI
Literature references
- The C terminus of p73 is essential for hippocampal development.;Amelio Ivano, Panatta Emanuele, Niklison-Chirou Maria Victoria, Steinert Joern R, Agostini Massimiliano, Morone Nobuhiro, Knight Richard A, Melino Gerry, ;2020;Proceedings of the National Academy of Sciences of the United States of America;117;15694-15701; 32571922
- P73 C-terminus is dispensable for multiciliogenesis.;Buckley Niall, Panatta Emanuele, Morone Nobuhiro, Noguchi Masafumi, Scorrano Luca, Knight Richard A, Amelio Ivano, Melino Gerry, ;2020;Cell cycle (Georgetown, Tex.);19;1833-1845; 32584647