C57BL/6NCrl-Rras2em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:13056
International strain nameC57BL/6NCrl-Rras2em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolRras2em1(IMPC)Ccpcz
Gene/Transgene symbolRras2

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • abnormal urinary bladder morphology / IMPC
  • abnormal thymus morphology / IMPC
  • enlarged thymus / IMPC
  • abnormal uterus morphology / IMPC
  • decreased body weight / IMPC
  • abnormal kidney morphology / IMPC
  • increased NK cell number / IMPC
  • hydrometra / IMPC
IMPC phenotypes (gene matching)
  • abnormal uterus morphology / IMPC
  • increased NK cell number / IMPC
  • abnormal thymus morphology / IMPC
  • hydrometra / IMPC
  • decreased body weight / IMPC
  • abnormal urinary bladder morphology / IMPC
  • enlarged thymus / IMPC
  • abnormal kidney morphology / IMPC
MGI phenotypes (gene matching)
  • spleen hypoplasia / MGI
  • increased body size / MGI
  • retinal degeneration / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal B cell physiology / MGI
  • abnormal retinal vasculature morphology / MGI
  • maternal effect / MGI
  • increased tumor growth/size / MGI
  • abnormal retinal photoreceptor layer morphology / MGI
  • abnormal retinal outer plexiform layer morphology / MGI
  • abnormal CD8-positive, alpha-beta T cell physiology / MGI
  • decreased spleen weight / MGI
  • decreased B cell number / MGI
  • decreased T cell number / MGI
  • decreased B cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal dendritic cell morphology / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • decreased memory T cell number / MGI
  • decreased follicular B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • abnormal B cell activation / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • thin retinal outer nuclear layer / MGI
  • abnormal lymph node germinal center morphology / MGI
  • increased total body fat amount / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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