IMPC phenotypes (gene matching)
C57BL/6J-Ctnnb1em1H/H
| Status | Available to order |
| EMMA ID | EM:13037 |
| International strain name | C57BL/6J-Ctnnb1em1H/H |
| Alternative name | CTNNB1-H720X-EM1-B6 |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Ctnnb1em1H |
| Gene/Transgene symbol | Ctnnb1 |
Information from provider
| Provider | MRC-Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:UnknownHeterozygous:None |
| Breeding history | Co-isogenic on original background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Craniopharyngioma / Orphanet_54595
- Desmoid tumor / Orphanet_873
- Pilomatrixoma / Orphanet_91414
- Familial exudative vitreoretinopathy / Orphanet_891
- Severe intellectual disability-progressive spastic diplegia syndrome / Orphanet_404473
MGI phenotypes (gene matching)
- growth retardation of molars / MGI
- increased leukocyte cell number / MGI
- increased granulocyte number / MGI
- broad head / MGI
- abnormal coat/ hair morphology / MGI
- absent hair follicles / MGI
- decreased hair follicle number / MGI
- alopecia / MGI
- abnormal head morphology / MGI
- microcephaly / MGI
- abnormal cranium morphology / MGI
- domed cranium / MGI
- flattened snout / MGI
- gastrointestinal hemorrhage / MGI
- abnormal small intestine morphology / MGI
- abnormal foot pad morphology / MGI
- kinked tail / MGI
- abnormal sweat gland morphology / MGI
- tremors / MGI
- abnormal tongue morphology / MGI
- decreased corpus callosum size / MGI
- forebrain hypoplasia / MGI
- small cerebellum / MGI
- decreased body size / MGI
- sparse vibrissae / MGI
- anophthalmia / MGI
- microphthalmia / MGI
- ocular hypertelorism / MGI
- cataract / MGI
- dry eyes / MGI
- impaired coordination / MGI
- reduced long term potentiation / MGI
- hunched posture / MGI
- abnormal coat appearance / MGI
- impaired balance / MGI
- abnormal vocalization / MGI
- abnormal germ layer development / MGI
- abnormal ectoderm development / MGI
- abnormal mesoderm development / MGI
- absent mesoderm / MGI
- abnormal gastrulation / MGI
- failure to gastrulate / MGI
- decreased embryo size / MGI
- abnormal proximal-distal axis patterning / MGI
- absent amniotic folds / MGI
- increased inflammatory response / MGI
- increased susceptibility to otitis media / MGI
- conjunctivitis / MGI
- decreased litter size / MGI
- deafness / MGI
- blindness / MGI
- abnormal hair growth / MGI
- premature death / MGI
- abnormal developmental patterning / MGI
- abnormal extraembryonic tissue morphology / MGI
- abnormal eye morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal cervical lymph node morphology / MGI
- increased intestinal adenoma incidence / MGI
- abnormal macrophage physiology / MGI
- abnormal inner cell mass morphology / MGI
- small olfactory bulb / MGI
- abnormal operant conditioning behavior / MGI
- absent Peyer's patches / MGI
- increased intestinal adenocarcinoma incidence / MGI
- no phenotypic analysis / MGI
- absent allantois / MGI
- early eyelid opening / MGI
- abnormal forebrain development / MGI
- abnormal intestinal goblet cell morphology / MGI
- abnormal hair follicle development / MGI
- abnormal embryonic epiblast morphology / MGI
- increased hepatocyte apoptosis / MGI
- liver hemorrhage / MGI
- abnormal craniofacial development / MGI
- abnormal nitric oxide homeostasis / MGI
- embryonic growth retardation / MGI
- abnormal globus pallidus morphology / MGI
- absent maxilla / MGI
- abnormal nasal capsule morphology / MGI
- abnormal synaptic vesicle clustering / MGI
- short incisors / MGI
- increased susceptibility to parasitic infection / MGI
- lethargy / MGI
- abnormal rostral-caudal axis patterning / MGI
- increased brain size / MGI
- narrow eye opening / MGI
- abnormal corneal stroma morphology / MGI
- growth retardation of incisors / MGI
- abnormal corneal epithelium morphology / MGI
- absent Meibomian glands / MGI
- small pharyngeal arch / MGI
- small molars / MGI
- decreased Peyer's patch number / MGI
- small Peyer's patches / MGI
- abnormal spatial reference memory / MGI
- abnormal peripheral lymph node morphology / MGI
- absent peripheral lymph nodes / MGI
- facial cleft / MGI
- decreased prepulse inhibition / MGI
- impaired contextual conditioning behavior / MGI
- small brachial lymph nodes / MGI
- small axillary lymph nodes / MGI
- absent popliteal lymph nodes / MGI
- abnormal hippocampus neuron morphology / MGI
- abnormal vibrissa follicle morphology / MGI
- increased gastrointestinal tumor incidence / MGI
- abnormal mandibular prominence morphology / MGI
- abnormal maxillary prominence morphology / MGI
- perinatal lethality, complete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- increased hair follicle apoptosis / MGI
- abnormal head size / MGI
- increased striatum area / MGI
- Harderian gland atrophy / MGI
- keratoconjunctivitis sicca / MGI
- abnormal eyelid margin morphology / MGI
- enlarged thalamus / MGI
- abnormal anterior head development / MGI
- misaligned incisors / MGI