C57BL/6J-Cntnap2^em3H/H

Status	Available to order
EMMA ID	EM:13027
International strain name	C57BL/6J-Cntnap2^em3H/H
Alternative name	CNTNAP2-FLOX-EM3-B6
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Cntnap2^em3H
Gene/Transgene symbol	Cntnap2

Information from provider

Provider	MRC-Harwell
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	For detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic information	Homozygous: Unknown Heterozygous: None
Breeding history	Co-isogenic on original background
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Pitt-Hopkins-like syndrome / Orphanet_221150
Cortical dysplasia-focal epilepsy syndrome / Orphanet_163681

IMPC phenotypes (gene matching)

increased exploration in new environment / IMPC

MGI phenotypes (gene matching)

abnormal corpus callosum morphology / MGI
decreased body size / MGI
social withdrawal / MGI
hyperactivity / MGI
increased stereotypic behavior / MGI
increased grooming behavior / MGI
abnormal nest building behavior / MGI
abnormal motor coordination/balance / MGI
abnormal olfaction / MGI
seizures / MGI
astrocytosis / MGI
abnormal response to novel odor / MGI
nervous system phenotype / MGI
decreased thermal nociceptive threshold / MGI
abnormal brain interneuron morphology / MGI
abnormal neuron physiology / MGI
abnormal brain wave pattern / MGI
behavior/neurological phenotype / MGI
abnormal neuronal migration / MGI
environmentally induced seizures / MGI
cognitive inflexibility / MGI
abnormal inhibitory learning / MGI
decreased vocalization / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6J-Cntnap2em3H/H