IMPC phenotypes (gene matching)
B6;129-Tmsb4xtm1Prri/H
| Status | Available to order |
| EMMA ID | EM:01301 |
| International strain name | B6;129-Tmsb4xtm1Prri/H |
| Alternative name | Tmsb4x |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tmsb4xtm1Prri |
| Gene/Transgene symbol | Tmsb4x |
Information from provider
| Provider | Martin Turner |
| Provider affiliation | Babraham Institute |
| Genetic information | In this knock-out line B-lymphocyte development is impaired. |
| Phenotypic information | Impairment of B-lymphocyte development and immune deficient. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
- abnormal blood vessel morphology / MGI
- internal hemorrhage / MGI
- intracranial hemorrhage / MGI
- thin myocardium / MGI
- abnormal arteriole morphology / MGI
- hemopericardium / MGI
- vision/eye phenotype / MGI
- heart hemorrhage / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- abnormal vascular smooth muscle development / MGI
MGI phenotypes (gene matching)
- abnormal blood vessel morphology / MGI
- internal hemorrhage / MGI
- intracranial hemorrhage / MGI
- no abnormal phenotype detected / MGI
- thin myocardium / MGI
- abnormal arteriole morphology / MGI
- hemopericardium / MGI
- cardiovascular system phenotype / MGI
- vision/eye phenotype / MGI
- heart hemorrhage / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- abnormal vascular smooth muscle development / MGI
Literature references
- Essential role for thymosin β4 in regulating vascular smooth muscle cell development and vessel wall stability.;Rossdeutsch Alex, Smart Nicola, Dubé Karina N, Turner Martin, Riley Paul R, ;2012;Circulation research;111;e89-102; 22723298