| Status | Available to order |
| EMMA ID | EM:00130 |
| International strain name | B6;129-Lta/Tnftm1Fda/Orl |
| Alternative name | LT-a TNF-a |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Lta/Tnftm1Fda |
| Gene/Transgene symbol | Lta |
| Provider | F Dautry |
| Provider affiliation | c/o CDTA-Orleans |
| Phenotypic information | Mutant mice deficient in lymphotoxin A (Lta or LT-alpha) and tumor necrosis factors (Tnf or TNF-alpha) genes, by homologous recombination (insertion of neo gene with deletion of all the Lta gene and a part of the Tnf gene). The tumor necrosis factors (TNF and LTA) are important mediators of the immune and inflammatory responses. The heterozygous mice have 20- to 100-fold lower TNF levels in circulation than the wild-type mice. Moreover, the heterozygous animals have an increased bacterial load following Listeria monocytogenes infection. |
| Breeding history | R1 ES cells (129/Sv); chimaeras crossed to C57BL/6 and then intercrossed. |
| References |
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| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
