B6J.129S2-Ncor2tm1.1Ics/Ics

Status

Available to order

EMMA IDEM:12999
Citation informationRRID:IMSR_EM:12999 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6J.129S2-Ncor2tm1.1Ics/Ics
Alternative nameNcor2 CM
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolNcor2tm1.1Ics
Gene/Transgene symbolNcor2

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
NA

Heterozygous:
NA
Breeding history5 backcross generations to C57BL/6J
References
  • Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.;Sun Zheng, Feng Dan, Fang Bin, Mullican Shannon E, You Seo-Hee, Lim Hee-Woong, Everett Logan J, Nabel Christopher S, Li Yun, Selvakumaran Vignesh, Won Kyoung-Jae, Lazar Mitchell A, ;2013;Molecular cell;52;769-82; 24268577
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal tail movements / IMPC
  • increased startle reflex / IMPC
  • abnormal placenta morphology / IMPC
  • increased prepulse inhibition / IMPC
  • abnormal blood vessel morphology / IMPC
  • persistence of hyaloid vascular system / IMPC
  • abnormal placenta vasculature / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • embryonic growth retardation / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased lean body mass / IMPC
  • edema / IMPC
  • abnormal craniofacial morphology / IMPC
  • long tibia / IMPC
  • abnormal retina morphology / IMPC

Literature references

  • Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.;Sun Zheng, Feng Dan, Fang Bin, Mullican Shannon E, You Seo-Hee, Lim Hee-Woong, Everett Logan J, Nabel Christopher S, Li Yun, Selvakumaran Vignesh, Won Kyoung-Jae, Lazar Mitchell A, ;2013;Molecular cell;52;769-82; 24268577

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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