IMPC phenotypes (gene matching)
B6J.129S2-Ncoa3tm1.2Ics/Ics
| Status | Available to order |
| EMMA ID | EM:12989 |
| International strain name | B6J.129S2-Ncoa3tm1.2Ics/Ics |
| Alternative name | SRC3 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ncoa3tm1.2Ics |
| Gene/Transgene symbol | Ncoa3 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:not knownHeterozygous:not known |
| Breeding history | 6 backcross generations |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal adipose tissue morphology / MGI
- lowered ear position / MGI
- decreased circulating HDL cholesterol level / MGI
- increased leukocyte cell number / MGI
- decreased cell proliferation / MGI
- small liver / MGI
- abnormal mammary gland development / MGI
- abnormal branching of the mammary ductal tree / MGI
- enlarged spleen / MGI
- abnormal vagina epithelium morphology / MGI
- increased body weight / MGI
- decreased body weight / MGI
- decreased body size / MGI
- hypoactivity / MGI
- abnormal eating behavior / MGI
- hyperglycemia / MGI
- decreased embryo size / MGI
- postnatal growth retardation / MGI
- decreased brown adipose tissue amount / MGI
- decreased white adipose tissue amount / MGI
- decreased litter size / MGI
- delayed sexual maturation / MGI
- increased B cell derived lymphoma incidence / MGI
- abnormal glucose homeostasis / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- decreased susceptibility to hepatic steatosis / MGI
- abnormal exercise endurance / MGI
- abnormal spleen red pulp morphology / MGI
- abnormal lymphopoiesis / MGI
- disproportionate dwarf / MGI
- delayed vaginal opening / MGI
- decreased circulating triglyceride level / MGI
- decreased circulating glucagon level / MGI
- decreased circulating free fatty acid level / MGI
- decreased circulating insulin level / MGI
- increased insulin sensitivity / MGI
- abnormal skeletal muscle fiber morphology / MGI
- thrombocytopenia / MGI
- decreased ovulation rate / MGI
- decreased liver weight / MGI
- oliguria / MGI
- abnormal female reproductive system physiology / MGI
- abnormal defecation / MGI
- abnormal hormone level / MGI
- increased incidence of tumors by chemical induction / MGI
- decreased circulating insulin-like growth factor I level / MGI
- increased circulating insulin-like growth factor I level / MGI
- increased energy expenditure / MGI
- decreased adiponectin level / MGI
- abnormal B cell morphology / MGI
- increased lymphocyte cell number / MGI
- increased B cell number / MGI
- abnormal cell differentiation / MGI
- cachexia / MGI
- increased B cell proliferation / MGI
- decreased circulating cholesterol level / MGI
- decreased circulating estradiol level / MGI
- increased oxygen consumption / MGI
- decreased oxygen consumption / MGI
- improved glucose tolerance / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- increased T cell proliferation / MGI
- homeostasis/metabolism phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- decreased body temperature / MGI
- decreased circulating glucose level / MGI
- abnormal cell physiology / MGI
- decreased susceptibility to diet-induced obesity / MGI
- increased circulating leptin level / MGI
- increased fat cell size / MGI
- abnormal epididymal fat pad morphology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased spleen germinal center size / MGI
- increased circulating tumor necrosis factor level / MGI
- increased tumor necrosis factor secretion / MGI
- increased circulating interleukin-6 level / MGI
- increased circulating interleukin-1 beta level / MGI
- decreased interleukin-1 beta secretion / MGI
- increased interleukin-6 secretion / MGI
- increased susceptibility to endotoxin shock / MGI
- increased carbon dioxide production / MGI
- decreased carbon dioxide production / MGI
- prolonged estrous cycle / MGI
- abnormal brown fat cell morphology / MGI
- decreased brown fat cell lipid droplet size / MGI
- decreased white fat cell size / MGI
- decreased brown fat cell size / MGI
- decreased epididymal fat pad weight / MGI
- decreased splenocyte apoptosis / MGI
- increased liver triglyceride level / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- increased total body fat amount / MGI
- decreased total body fat amount / MGI
- rough coat / MGI
- increased respiratory quotient / MGI
- increased liver glycogen level / MGI
- impaired adaptive thermogenesis / MGI
- preweaning lethality, incomplete penetrance / MGI
- increased mitochondria size / MGI
- decreased fibroblast cell migration / MGI
- impaired exercise endurance / MGI
- increased lymphoma incidence / MGI