IMPC phenotypes (gene matching)
B6J.129S2-Ncoa3tm1.2Ics/Ics
| Status | Available to order |
| EMMA ID | EM:12989 |
| Citation information | RRID:IMSR_EM:12989 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6J.129S2-Ncoa3tm1.2Ics/Ics |
| Alternative name | SRC3 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ncoa3tm1.2Ics |
| Gene/Transgene symbol | Ncoa3 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:not knownHeterozygous:not known |
| Breeding history | 6 backcross generations |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal adipose tissue morphology / MGI
- lowered ear position / MGI
- decreased circulating HDL cholesterol level / MGI
- increased leukocyte cell number / MGI
- decreased cell proliferation / MGI
- small liver / MGI
- abnormal mammary gland development / MGI
- abnormal branching of the mammary ductal tree / MGI
- enlarged spleen / MGI
- abnormal vagina epithelium morphology / MGI
- increased body weight / MGI
- decreased body weight / MGI
- decreased body size / MGI
- hypoactivity / MGI
- abnormal eating behavior / MGI
- hyperglycemia / MGI
- decreased embryo size / MGI
- postnatal growth retardation / MGI
- decreased brown adipose tissue amount / MGI
- decreased white adipose tissue amount / MGI
- decreased litter size / MGI
- delayed sexual maturation / MGI
- increased B cell derived lymphoma incidence / MGI
- abnormal glucose homeostasis / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- decreased susceptibility to hepatic steatosis / MGI
- abnormal exercise endurance / MGI
- abnormal spleen red pulp morphology / MGI
- abnormal lymphopoiesis / MGI
- disproportionate dwarf / MGI
- delayed vaginal opening / MGI
- decreased circulating triglyceride level / MGI
- decreased circulating glucagon level / MGI
- decreased circulating free fatty acid level / MGI
- decreased circulating insulin level / MGI
- increased insulin sensitivity / MGI
- abnormal skeletal muscle fiber morphology / MGI
- thrombocytopenia / MGI
- decreased ovulation rate / MGI
- decreased liver weight / MGI
- oliguria / MGI
- abnormal female reproductive system physiology / MGI
- abnormal defecation / MGI
- abnormal hormone level / MGI
- increased incidence of tumors by chemical induction / MGI
- decreased circulating insulin-like growth factor I level / MGI
- increased circulating insulin-like growth factor I level / MGI
- increased energy expenditure / MGI
- decreased adiponectin level / MGI
- abnormal B cell morphology / MGI
- increased lymphocyte cell number / MGI
- increased B cell number / MGI
- abnormal cell differentiation / MGI
- cachexia / MGI
- increased B cell proliferation / MGI
- decreased circulating cholesterol level / MGI
- decreased circulating estradiol level / MGI
- increased oxygen consumption / MGI
- decreased oxygen consumption / MGI
- improved glucose tolerance / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- increased T cell proliferation / MGI
- homeostasis/metabolism phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- decreased body temperature / MGI
- decreased circulating glucose level / MGI
- abnormal cell physiology / MGI
- decreased susceptibility to diet-induced obesity / MGI
- increased circulating leptin level / MGI
- increased fat cell size / MGI
- abnormal epididymal fat pad morphology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased spleen germinal center size / MGI
- increased circulating tumor necrosis factor level / MGI
- increased tumor necrosis factor secretion / MGI
- increased circulating interleukin-6 level / MGI
- increased circulating interleukin-1 beta level / MGI
- decreased interleukin-1 beta secretion / MGI
- increased interleukin-6 secretion / MGI
- increased susceptibility to endotoxin shock / MGI
- increased carbon dioxide production / MGI
- decreased carbon dioxide production / MGI
- prolonged estrous cycle / MGI
- abnormal brown fat cell morphology / MGI
- decreased brown fat cell lipid droplet size / MGI
- decreased white fat cell size / MGI
- decreased brown fat cell size / MGI
- decreased epididymal fat pad weight / MGI
- decreased splenocyte apoptosis / MGI
- increased liver triglyceride level / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- increased total body fat amount / MGI
- decreased total body fat amount / MGI
- rough coat / MGI
- increased respiratory quotient / MGI
- increased liver glycogen level / MGI
- impaired adaptive thermogenesis / MGI
- preweaning lethality, incomplete penetrance / MGI
- increased mitochondria size / MGI
- decreased fibroblast cell migration / MGI
- impaired exercise endurance / MGI
- increased lymphoma incidence / MGI