B6J.129S2-Nr3c2tm1.2Ics/Ics

Status

Available to order

EMMA IDEM:12978
International strain nameB6J.129S2-Nr3c2tm1.2Ics/Ics
Alternative nameMR KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolNr3c2tm1.2Ics
Gene/Transgene symbolNr3c2

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
https://www.mousephenotype.org/data/genes/MGI:99459

Heterozygous:
https://www.mousephenotype.org/data/genes/MGI:99459
Breeding history7 backcross generations
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased startle reflex / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (gene matching)
  • decreased body weight / MGI
  • weight loss / MGI
  • dehydration / MGI
  • abnormal ion homeostasis / MGI
  • postnatal lethality / MGI
  • increased hematocrit / MGI
  • increased circulating aldosterone level / MGI
  • abnormal juxtaglomerular apparatus morphology / MGI
  • increased circulating renin level / MGI
  • abnormal renal glomerulus morphology / MGI
  • renal/urinary system phenotype / MGI
  • increased renin activity / MGI
  • increased circulating potassium level / MGI
  • decreased circulating sodium level / MGI
  • increased urine sodium level / MGI
  • abnormal renal sodium reabsorbtion / MGI
  • hypovolemia / MGI
  • postnatal lethality, complete penetrance / MGI
  • abnormal macula densa morphology / MGI
  • abnormal juxtaglomerular cell morphology / MGI
  • abnormal extraglomerular mesangial cell morphology / MGI
  • abnormal renal sodium ion transport / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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