- abnormal liver physiology / MGI
- abnormal adrenal gland morphology / MGI
- enlarged adrenal glands / MGI
- absent adrenal medulla / MGI
- absent adrenergic chromaffin cells / MGI
- enlarged adrenocortical cells / MGI
- abnormal lung morphology / MGI
- abnormal lung development / MGI
- atelectasis / MGI
- thick pulmonary interalveolar septum / MGI
- cyanosis / MGI
- absent circulating adrenaline / MGI
- increased circulating corticosterone level / MGI
- increased circulating adrenocorticotropin level / MGI
- respiratory failure / MGI
- respiratory distress / MGI
- no abnormal phenotype detected / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal pulmonary alveolus epithelial cell morphology / MGI
- abnormal alveolocapillary membrane morphology / MGI
- decreased circulating adrenocorticotropin level / MGI
- decreased circulating corticosterone level / MGI
- increased circulating aldosterone level / MGI
- small adrenal glands / MGI
- decreased circulating testosterone level / MGI
- abnormal respiratory system development / MGI
- decreased macrophage cell number / MGI
- pulmonary hyperplasia / MGI
- abnormal surfactant secretion / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- increased mean systemic arterial blood pressure / MGI
- abnormal osteoblast physiology / MGI
- decreased B cell number / MGI
- abnormal blood-brain barrier function / MGI
- abnormal circulating corticosterone level / MGI
- renal/urinary system phenotype / MGI
- adipose tissue phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- skeleton phenotype / MGI
- increased renin activity / MGI
- increased lung weight / MGI
- decreased circulating noradrenaline level / MGI
- impaired lung alveolus development / MGI
- increased systemic arterial systolic blood pressure / MGI
- increased circulating angiotensinogen level / MGI
- decreased T cell apoptosis / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal adrenal cortex morphology / MGI
- enlarged adrenocortical cell nuclei / MGI
- abnormal adrenal gland zona glomerulosa morphology / MGI
- abnormal adrenal gland zona fasciculata morphology / MGI
- abnormal adrenal gland zona reticularis morphology / MGI
- thin adrenal cortex / MGI
- abnormal osteoblast differentiation / MGI
- abnormal adrenal chromaffin cell morphology / MGI
- decreased survivor rate / MGI
- abnormal physiological response to xenobiotic / MGI
- decreased erythroid progenitor cell number / MGI
- abnormal thymocyte apoptosis / MGI
- increased liver triglyceride level / MGI
- increased type II pneumocyte number / MGI
- decreased type I pneumocyte number / MGI
- abnormal branching involved in terminal bronchiole morphogenesis / MGI
- postnatal lethality, complete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- decreased noradrenaline level / MGI
- decreased adrenaline level / MGI
B6J.129S2-Nr3c1tm1.1Ics/Ics
Status | Available to order |
EMMA ID | EM:12976 |
International strain name | B6J.129S2-Nr3c1tm1.1Ics/Ics |
Alternative name | GR CM |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Nr3c1tm1.1Ics |
Gene/Transgene symbol | Nr3c1 |
Information from provider
Provider | ICS, Institut Clinique de la Souris |
Provider affiliation | ICS, Institut Clinique de la Souris |
Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
Phenotypic information | Homozygous:NAHeterozygous:NA |
Breeding history | 6 backcross generations |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Generalized glucocorticoid resistance syndrome / Orphanet_786
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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