B6J.129S2-Hnf4atm1.2Ics/Ics

Status

Available to order

EMMA IDEM:12952
International strain nameB6J.129S2-Hnf4atm1.2Ics/Ics
Alternative nameHNF4a KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolHnf4atm1.2Ics
Gene/Transgene symbolHnf4a

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
not known

Heterozygous:
not known
Breeding history6 backcross generations
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating HDL cholesterol level / IMPC
  • increased total retina thickness / IMPC
  • persistence of hyaloid vascular system / IMPC
  • enlarged thyroid gland / IMPC
  • abnormal retina blood vessel morphology / IMPC
  • increased circulating bilirubin level / IMPC
  • increased circulating calcium level / IMPC
  • abnormal lens morphology / IMPC
  • abnormal retina morphology / IMPC
  • cataract / IMPC
  • improved glucose tolerance / IMPC
  • abnormal retina vasculature morphology / IMPC
  • decreased body weight / IMPC
  • increased circulating cholesterol level / IMPC
MGI phenotypes (gene matching)
  • abnormal embryo development / MGI
  • abnormal ectoderm development / MGI
  • absent mesoderm / MGI
  • abnormal gastrulation / MGI
  • decreased embryo size / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • abnormal lipid homeostasis / MGI
  • no abnormal phenotype detected / MGI
  • abnormal primitive streak formation / MGI
  • increased circulating ketone body level / MGI
  • hepatic steatosis / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating free fatty acid level / MGI
  • absent allantois / MGI
  • increased ectoderm apoptosis / MGI
  • embryonic growth retardation / MGI
  • hypokalemia / MGI
  • decreased circulating iron level / MGI
  • absent amnion / MGI
  • decreased circulating cholesterol level / MGI
  • impaired glucose tolerance / MGI
  • increased circulating bilirubin level / MGI
  • absent chorion / MGI
  • embryonic lethality, complete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI
  • delayed gastrulation / MGI
  • small visceral yolk sac / MGI
  • increased embryonic tissue cell apoptosis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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