B6J.129S2-Nr1h4tm1.2Ics/Ics

Status

Available to order

EMMA IDEM:12944
International strain nameB6J.129S2-Nr1h4tm1.2Ics/Ics
Alternative nameFXRa KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolNr1h4tmIcs
Gene/Transgene symbolNr1h4

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
https://www.mousephenotype.org/data/genes/MGI:1352464

Heterozygous:
https://www.mousephenotype.org/data/genes/MGI:1352464
Breeding history5 backcross generations
ReferencesNone available
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased mean corpuscular volume / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased startle reflex / IMPC
  • increased circulating triglyceride level / IMPC
  • abnormal tail movements / IMPC
  • decreased prepulse inhibition / IMPC
  • increased lactate dehydrogenase level / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased locomotor activity / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased circulating serum albumin level / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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