B6J.129S2-Pparatm1.1Ics/Ics
Status | Available to order |
EMMA ID | EM:12930 |
International strain name | B6J.129S2-Pparatm1.1Ics/Ics |
Alternative name | PPARa CM |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Pparatm1.1Ics |
Gene/Transgene symbol | Ppara |
Information from provider
Provider | ICS, Institut Clinique de la Souris |
Provider affiliation | ICS, Institut Clinique de la Souris |
Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
Phenotypic information | Homozygous:NAHeterozygous:NA |
Breeding history | 5 backcross generations |
References |
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Homozygous fertile | not known |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
IMPC phenotypes (gene matching)
Literature references
- Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.;Montagner Alexandra, Polizzi Arnaud, Fouché Edwin, Ducheix Simon, Lippi Yannick, Lasserre Frédéric, Barquissau Valentin, Régnier Marion, Lukowicz Céline, Benhamed Fadila, Iroz Alison, Bertrand-Michel Justine, Al Saati Talal, Cano Patricia, Mselli-Lakhal Laila, Mithieux Gilles, Rajas Fabienne, Lagarrigue Sandrine, Pineau Thierry, Loiseau Nicolas, Postic Catherine, Langin Dominique, Wahli Walter, Guillou Hervé, ;2016;Gut;65;1202-14; 26838599
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