B6J.129S2-Pparatm1.1Ics/Ics

Status

Available to order

EMMA IDEM:12930
International strain nameB6J.129S2-Pparatm1.1Ics/Ics
Alternative namePPARa CM
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolPparatm1.1Ics
Gene/Transgene symbolPpara

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
NA

Heterozygous:
NA
Breeding history5 backcross generations
References
  • Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.;Montagner Alexandra, Polizzi Arnaud, Fouché Edwin, Ducheix Simon, Lippi Yannick, Lasserre Frédéric, Barquissau Valentin, Régnier Marion, Lukowicz Céline, Benhamed Fadila, Iroz Alison, Bertrand-Michel Justine, Al Saati Talal, Cano Patricia, Mselli-Lakhal Laila, Mithieux Gilles, Rajas Fabienne, Lagarrigue Sandrine, Pineau Thierry, Loiseau Nicolas, Postic Catherine, Langin Dominique, Wahli Walter, Guillou Hervé, ;2016;Gut;65;1202-14; 26838599
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal skin coloration / IMPC
  • abnormal coat appearance / IMPC

Literature references

  • Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.;Montagner Alexandra, Polizzi Arnaud, Fouché Edwin, Ducheix Simon, Lippi Yannick, Lasserre Frédéric, Barquissau Valentin, Régnier Marion, Lukowicz Céline, Benhamed Fadila, Iroz Alison, Bertrand-Michel Justine, Al Saati Talal, Cano Patricia, Mselli-Lakhal Laila, Mithieux Gilles, Rajas Fabienne, Lagarrigue Sandrine, Pineau Thierry, Loiseau Nicolas, Postic Catherine, Langin Dominique, Wahli Walter, Guillou Hervé, ;2016;Gut;65;1202-14; 26838599

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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