IMPC phenotypes (gene matching)
B6J.129S2-Ncoa6tm1.2Ics/Ics
| Status | Available to order |
| EMMA ID | EM:12925 |
| International strain name | B6J.129S2-Ncoa6tm1.2Ics/Ics |
| Alternative name | RAP-250 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ncoa6tm1.2Ics |
| Gene/Transgene symbol | Ncoa6 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:not knownHeterozygous:not known |
| Breeding history | 12 backcross generations |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal triglyceride level / MGI
- abnormal vascular development / MGI
- abnormal heart morphology / MGI
- abnormal heart development / MGI
- thin ventricular wall / MGI
- trabecula carnea hypoplasia / MGI
- decreased hair follicle number / MGI
- oligodactyly / MGI
- abnormal liver development / MGI
- abnormal liver morphology / MGI
- small liver / MGI
- decreased hepatocyte number / MGI
- abnormal hepatocyte morphology / MGI
- dilated third ventricle / MGI
- abnormal hypothalamus morphology / MGI
- abnormal brain development / MGI
- thick epidermis / MGI
- abnormal lens morphology / MGI
- cataract / MGI
- small lens / MGI
- abnormal eye pigmentation / MGI
- abnormal blood vessel morphology / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- abnormal placenta development / MGI
- impaired wound healing / MGI
- delayed brain development / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- female infertility / MGI
- decreased litter size / MGI
- abnormal digit morphology / MGI
- abnormal lipid homeostasis / MGI
- disorganized myocardium / MGI
- thin myocardium / MGI
- heart hypoplasia / MGI
- delayed wound healing / MGI
- increased liver weight / MGI
- abnormal epicardium morphology / MGI
- abnormal vitelline vasculature morphology / MGI
- abnormal placenta vasculature / MGI
- abnormal embryonic hematopoiesis / MGI
- absent placental labyrinth / MGI
- absent olfactory bulb / MGI
- abnormal fetal cardiomyocyte proliferation / MGI
- pallor / MGI
- abnormal feces composition / MGI
- increased hepatocyte apoptosis / MGI
- embryonic growth retardation / MGI
- thin myocardium compact layer / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- dilated vasculature / MGI
- abnormal trophoblast layer morphology / MGI
- increased circulating cholesterol level / MGI
- abnormal heart ventricle morphology / MGI
- pericardial effusion / MGI
- abnormal myocardium layer morphology / MGI
- abnormal bile salt homeostasis / MGI
- reproductive system phenotype / MGI
- abnormal cell physiology / MGI
- impaired placental function / MGI
- abnormal fetal cardiomyocyte morphology / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased neuron number / MGI
- abnormal spongiotrophoblast cell morphology / MGI
- decreased erythroid progenitor cell number / MGI
- increased trophoblast giant cell number / MGI
- decreased birth weight / MGI
- decreased birth body size / MGI
- abnormal palatal shelf fusion at midline / MGI
- neonatal lethality, incomplete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased fibroblast proliferation / MGI
- decreased spongiotrophoblast size / MGI
- abnormal liver bud morphology / MGI
- increased sebaceous gland number / MGI
- increased fibroblast apoptosis / MGI
- small thalamus / MGI