C3;CAnN-Pde6brd1-2H/H

Status

Available to order

EMMA IDEM:01291
International strain nameC3;CAnN-Pde6brd1-2H/H
Alternative nameatrd5
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolPde6brd1-2H
Gene/Transgene symbolPde6b

Information from provider

ProviderCaroline Thaung
Provider affiliationMRC Mammalian Genetics Unit
Phenotypic informationSlow onset retinal degeneration. This is a recessive mutation. Homozygotes have retinal degeneration. Compound heterozygotes with Pdebrd1 in background have slightly faster disease.
References
  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal whole-body plethysmography / IMPC
  • decreased circulating amylase level / IMPC
  • atrophy / IMPC
  • decreased defecation amount / IMPC
  • decreased body weight / IMPC
  • abnormal heart morphology / IMPC
  • increased cellular hemoglobin content / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased body temperature / IMPC
  • increased circulating potassium level / IMPC
  • increased mean corpuscular volume / IMPC
  • decreased locomotor activity / IMPC
  • increased blood uric acid level / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
  • enlarged heart / IMPC
MGI phenotypes (allele matching)
  • retinal degeneration / MGI
MGI phenotypes (gene matching)
  • abnormal retinal rod cell morphology / MGI
  • abnormal retina morphology / MGI
  • retinal degeneration / MGI
  • decreased retinal photoreceptor cell number / MGI
  • blindness / MGI
  • abnormal retinal vasculature morphology / MGI
  • abnormal ocular fundus morphology / MGI
  • abnormal photoreceptor outer segment morphology / MGI
  • abnormal retinal outer nuclear layer morphology / MGI
  • abnormal rod electrophysiology / MGI
  • abnormal cone electrophysiology / MGI
  • vision/eye phenotype / MGI
  • abnormal Muller cell morphology / MGI
  • abnormal eye electrophysiology / MGI
  • decreased visual acuity / MGI
  • impaired pupillary reflex / MGI
  • abnormal optic disk morphology / MGI
  • retinal photoreceptor degeneration / MGI
  • retinal rod cell degeneration / MGI
  • absent retinal rod cells / MGI
  • thin retinal outer nuclear layer / MGI
  • retinal outer nuclear layer degeneration / MGI
  • absent photoreceptor outer segment / MGI
  • abnormal retinal blood vessel morphology / MGI
  • decreased total retina thickness / MGI

Literature references

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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