strain-details - INFRAFRONTIER

Information from provider

Status	Under development - register interest
EMMA ID	EM:12888
International strain name	C57BL/6NCrl-Fnip1^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Fnip1^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Fnip1

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Disease and phenotype information

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

IMPC phenotypes (allele matching)

increased neutrophil cell number / IMPC
abnormal heart morphology / IMPC
enlarged heart / IMPC
abnormal cecum morphology / IMPC
abnormal mammary gland morphology / IMPC
abnormal spleen morphology / IMPC
small spleen / IMPC
abnormal thymus morphology / IMPC
small thymus / IMPC
enlarged thymus / IMPC
abnormal skeletal muscle morphology / IMPC
decreased body weight / IMPC
decreased locomotor activity / IMPC
decreased startle reflex / IMPC
abnormal pancreas morphology / IMPC
abnormal inspiratory capacity / IMPC
dilated heart left ventricle / IMPC
increased thigmotaxis / IMPC
increased heart weight / IMPC
thick ventricular wall / IMPC
increased liver weight / IMPC
abnormal spine curvature / IMPC
decreased spleen weight / IMPC
decreased lymphocyte cell number / IMPC
improved glucose tolerance / IMPC
decreased heart rate / IMPC
thrombocytosis / IMPC
increased cardiac muscle contractility / IMPC
increased circulating iron level / IMPC
enlarged cecum / IMPC
decreased grip strength / IMPC
decreased red blood cell distribution width / IMPC
decreased respiratory quotient / IMPC
dilated aorta / IMPC
increased heart left ventricle size / IMPC
increased lung compliance / IMPC
decreased airway resistance / IMPC
decreased lung elastance / IMPC
decreased lung tissue damping / IMPC
increased cardiac stroke volume / IMPC
increased fasting circulating glucose level / IMPC
increased freezing behavior / IMPC

IMPC phenotypes (gene matching)

abnormal spleen morphology / IMPC
increased thigmotaxis / IMPC
abnormal heart morphology / IMPC
enlarged heart / IMPC
increased cardiac stroke volume / IMPC
decreased respiratory quotient / IMPC
small thymus / IMPC
small spleen / IMPC
abnormal thymus morphology / IMPC
decreased lung elastance / IMPC
increased fasting circulating glucose level / IMPC
decreased grip strength / IMPC
thick ventricular wall / IMPC
abnormal inspiratory capacity / IMPC
dilated heart left ventricle / IMPC
improved glucose tolerance / IMPC
increased heart left ventricle size / IMPC
enlarged thymus / IMPC
decreased heart rate / IMPC
dilated aorta / IMPC
decreased lymphocyte cell number / IMPC
abnormal skeletal muscle morphology / IMPC
enlarged cecum / IMPC
decreased lung tissue damping / IMPC
increased lung compliance / IMPC
increased cardiac muscle contractility / IMPC
decreased startle reflex / IMPC
abnormal mammary gland morphology / IMPC
increased liver weight / IMPC
decreased locomotor activity / IMPC
decreased airway resistance / IMPC
thrombocytosis / IMPC
abnormal pancreas morphology / IMPC
increased heart weight / IMPC
decreased red blood cell distribution width / IMPC
abnormal cecum morphology / IMPC
increased neutrophil cell number / IMPC
increased freezing behavior / IMPC
decreased spleen weight / IMPC
decreased body weight / IMPC
increased circulating iron level / IMPC
abnormal spine curvature / IMPC

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

C57BL/6NCrl-Fnip1^{em1(IMPC)Ccpcz}/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Fnip1em1(IMPC)Ccpcz/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Fnip1^{em1(IMPC)Ccpcz}/Ph