C57BL/6NCrl-Otop1^{em1(IMPC)Ccpcz}/Ph

Status	Under development - register interest
EMMA ID	EM:12876
International strain name	C57BL/6NCrl-Otop1^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Otop1^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Otop1

Information from provider

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)

abnormal spleen morphology / IMPC
abnormal thymus morphology / IMPC
enlarged thymus / IMPC
decreased body weight / IMPC
increased circulating aspartate transaminase level / IMPC

IMPC phenotypes (gene matching)

abnormal spleen morphology / IMPC
increased circulating aspartate transaminase level / IMPC
decreased body weight / IMPC
abnormal thymus morphology / IMPC
enlarged thymus / IMPC

MGI phenotypes (gene matching)

impaired coordination / MGI
abnormal posture / MGI
impaired swimming / MGI
impaired righting response / MGI
abnormal motor capabilities/coordination/movement / MGI
decreased vertical activity / MGI
abnormal vestibular ganglion morphology / MGI
absent otoliths / MGI
abnormal vestibular system physiology / MGI
absent linear vestibular evoked potential / MGI
head tilt / MGI
hearing/vestibular/ear phenotype / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6NCrl-Otop1em1(IMPC)Ccpcz/Ph