- increased monocyte cell number / MGI
- sparse hair / MGI
- lymphoid hyperplasia / MGI
- skin hyperplasia / MGI
- hyperkeratosis / MGI
- disheveled coat / MGI
- skin edema / MGI
- abnormal inflammatory response / MGI
- abnormal skin morphology / MGI
- abnormal macrophage physiology / MGI
- increased IgA level / MGI
- decreased basophil cell number / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- liver degeneration / MGI
- pallor / MGI
- liver hemorrhage / MGI
- skin inflammation / MGI
- increased spleen weight / MGI
- dermal hyperplasia / MGI
- decreased eosinophil cell number / MGI
- increased NK T cell number / MGI
- decreased NK T cell number / MGI
- increased circulating tumor necrosis factor level / MGI
- abnormal interferon secretion / MGI
- increased tumor necrosis factor secretion / MGI
- decreased interferon-beta secretion / MGI
- increased circulating interleukin-10 level / MGI
- increased circulating interleukin-6 level / MGI
- increased circulating interleukin-1 beta level / MGI
- increased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- increased susceptibility to endotoxin shock / MGI
- abnormal hair cycle anagen phase / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- postnatal lethality, complete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
C57BL/6NCrl-Tbk1em1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:12874 |
International strain name | C57BL/6NCrl-Tbk1em1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Tbk1em1(IMPC)Ccpcz |
Gene/Transgene symbol | Tbk1 |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Frontotemporal dementia with motor neuron disease / Orphanet_275872
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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