strain-details - INFRAFRONTIER

Information from provider

Status	Under development - register interest
EMMA ID	EM:12867
International strain name	C57BL/6NCrl-Xrcc5^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Xrcc5^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Xrcc5

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Disease and phenotype information

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

IMPC phenotypes (allele matching)

abnormal vertebrae morphology / IMPC
kyphosis / IMPC
scoliosis / IMPC
thin ventricular wall / IMPC
abnormal cranium morphology / IMPC
abnormal spleen morphology / IMPC
small spleen / IMPC
abnormal thymus morphology / IMPC
small thymus / IMPC
abnormal testis morphology / IMPC
small testis / IMPC
abnormal retina morphology / IMPC
hyperactivity / IMPC
decreased locomotor activity / IMPC
decreased exploration in new environment / IMPC
increased circulating triglyceride level / IMPC
male infertility / IMPC
female infertility / IMPC
increased mean platelet volume / IMPC
abnormal caudal vertebrae morphology / IMPC
short tibia / IMPC
increased thigmotaxis / IMPC
increased circulating alkaline phosphatase level / IMPC
decreased cardiac output / IMPC
increased kidney weight / IMPC
abnormal heart left ventricle morphology / IMPC
abnormal spine curvature / IMPC
abnormal vertebral arch morphology / IMPC
abnormal auditory brainstem response / IMPC
abnormal zygomatic bone morphology / IMPC
decreased circulating serum albumin level / IMPC
increased mean corpuscular hemoglobin / IMPC
increased grip strength / IMPC
decreased grip strength / IMPC
increased red blood cell distribution width / IMPC
abnormal retina blood vessel morphology / IMPC
aorta stenosis / IMPC
decreased heart left ventricle size / IMPC
decreased cardiac stroke volume / IMPC

IMPC phenotypes (gene matching)

abnormal retina morphology / IMPC
increased thigmotaxis / IMPC
increased red blood cell distribution width / IMPC
abnormal thymus morphology / IMPC
abnormal vertebral arch morphology / IMPC
abnormal testis morphology / IMPC
increased kidney weight / IMPC
abnormal zygomatic bone morphology / IMPC
decreased cardiac stroke volume / IMPC
decreased circulating serum albumin level / IMPC
thin ventricular wall / IMPC
abnormal heart left ventricle morphology / IMPC
abnormal spleen morphology / IMPC
abnormal auditory brainstem response / IMPC
small spleen / IMPC
male infertility / IMPC
abnormal vertebrae morphology / IMPC
small thymus / IMPC
decreased cardiac output / IMPC
abnormal spine curvature / IMPC
decreased grip strength / IMPC
abnormal caudal vertebrae morphology / IMPC
aorta stenosis / IMPC
increased circulating triglyceride level / IMPC
decreased exploration in new environment / IMPC
increased mean platelet volume / IMPC
short tibia / IMPC
female infertility / IMPC
small testis / IMPC
decreased heart left ventricle size / IMPC
abnormal cranium morphology / IMPC
hyperactivity / IMPC
abnormal retina blood vessel morphology / IMPC
increased grip strength / IMPC
increased mean corpuscular hemoglobin / IMPC
increased circulating alkaline phosphatase level / IMPC
scoliosis / IMPC
decreased locomotor activity / IMPC
kyphosis / IMPC

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

C57BL/6NCrl-Xrcc5^{em1(IMPC)Ccpcz}/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Xrcc5em1(IMPC)Ccpcz/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Xrcc5^{em1(IMPC)Ccpcz}/Ph