Sprague Dawley rat Rno1_DelSult1a1-Spn X Rno1_DupSult1a1-Spn/YahIcsOrl
| Status | Available to order |
| EMMA ID | EM:12851 |
| International strain name | Sprague Dawley rat Rno1_DelSult1a1-Spn X Rno1_DupSult1a1-Spn/YahIcsOrl |
| Alternative name | Sprague Dawley rat Rno1_Del |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Sult1a-Spn |
| Gene/Transgene symbol | Sult1a-Spn |
Information from provider
| Provider | Yann Herault |
| Provider affiliation | Translational Medicine and Neurogenetics, IGBMC |
| Genetic information | Sprague Dawley rat. Cross between EM:11821 and EM:11822 EM:11821: Deletion of the genetic interval Sult1a1-Spn: we targeted an extended sequence of the whole locus from one allele and the CRISPR/Cas9 system allowed us to remove the region encompassing 28 genes, orthologous to human. EM:11822: Tandem duplication of the genetic interval between Sult1a1 and Spn genes using CRISPR/Cas9 engineering. We targeted the genetic interval borders from one allele and the CRISPR/Cas9 system allowed us to cut and transpose those sequences to the same locus on the second allele. |
| Phenotypic information | Homozygous:Not KnownHeterozygous:Under investigation |
| Breeding history | Backcross on Sprague Dawley background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous rat Sprague-Dawley, wild-type rat Sprague-Dawley |
| Stage of embryos | 2-cell |