C57BL/6NCrl-Casp8^{em1(IMPC)Ccpcz}/Ph

Status	Under development - register interest
EMMA ID	EM:12849
International strain name	C57BL/6NCrl-Casp8^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Casp8^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Casp8

Information from provider

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Adult hepatocellular carcinoma / Orphanet_210159
Autoimmune lymphoproliferative syndrome with recurrent viral infections / Orphanet_275517

IMPC phenotypes (allele matching)

abnormal heart morphology / IMPC
enlarged heart / IMPC
abnormal liver morphology / IMPC
small liver / IMPC
abnormal kidney morphology / IMPC
small kidney / IMPC
preweaning lethality, incomplete penetrance / IMPC
embryonic lethality prior to tooth bud stage / IMPC

IMPC phenotypes (gene matching)

abnormal heart morphology / IMPC
small kidney / IMPC
small liver / IMPC
abnormal kidney morphology / IMPC
preweaning lethality, incomplete penetrance / IMPC
enlarged heart / IMPC
abnormal liver morphology / IMPC
embryonic lethality prior to tooth bud stage / IMPC

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6NCrl-Casp8em1(IMPC)Ccpcz/Ph