C57BL/6NCrl-Hckem1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:12840
International strain nameC57BL/6NCrl-Hckem1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolHckem1(IMPC)Ccpcz
Gene/Transgene symbolHck

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

MGI phenotypes (gene matching)
  • atelectasis / MGI
  • thick pulmonary interalveolar septum / MGI
  • overexpanded pulmonary alveoli / MGI
  • abnormal immune system physiology / MGI
  • impaired macrophage phagocytosis / MGI
  • abnormal inflammatory response / MGI
  • lung inflammation / MGI
  • respiratory distress / MGI
  • emphysema / MGI
  • increased lung adenocarcinoma incidence / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • abnormal macrophage physiology / MGI
  • abnormal neutrophil physiology / MGI
  • pulmonary hyperplasia / MGI
  • increased eosinophil cell number / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • pulmonary fibrosis / MGI
  • abnormal alveolar macrophage morphology / MGI
  • increased circulating tumor necrosis factor level / MGI
  • increased interleukin-5 secretion / MGI
  • abnormal respiratory epithelium morphology / MGI
  • respiratory epithelium hypertrophy / MGI
  • decreased lung elastance / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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