IMPC phenotypes (allele matching)
- preweaning lethality, complete penetrance / IMPC
C57BL/6NCrl-Erbb2tm1b(EUCOMM)Hmgu/Ieg
| Status | Available to order |
| EMMA ID | EM:12826 |
| International strain name | C57BL/6NCrl-Erbb2tm1b(EUCOMM)Hmgu/Ieg |
| Alternative name | HEPD0668_3_H11 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Erbb2tm1b(EUCOMM)Hmgu |
| Gene/Transgene symbol | Erbb2 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0668_3_H11. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hirschsprung disease / Orphanet_388
IMPC phenotypes (gene matching)
- preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
- enlarged heart / MGI
- thin ventricular wall / MGI
- absent myocardial trabeculae / MGI
- absent trabeculae carneae / MGI
- decreased atrioventricular cushion size / MGI
- abnormal motor neuron innervation pattern / MGI
- abnormal oligodendrocyte morphology / MGI
- abnormal dorsal root ganglion morphology / MGI
- abnormal sensory neuron morphology / MGI
- abnormal sensory neuron innervation pattern / MGI
- absent primary muscle spindle / MGI
- partial loss of secondary muscle spindle / MGI
- abnormal sympathetic ganglion morphology / MGI
- abnormal cranial nerve morphology / MGI
- abnormal trigeminal nerve morphology / MGI
- abnormal glossopharyngeal nerve morphology / MGI
- abnormal vagus nerve morphology / MGI
- abnormal hypoglossal nerve morphology / MGI
- abnormal phrenic nerve morphology / MGI
- defasiculated phrenic nerve / MGI
- abnormal cranial ganglia morphology / MGI
- abnormal geniculate ganglion morphology / MGI
- abnormal petrosal ganglion morphology / MGI
- abnormal trigeminal ganglion morphology / MGI
- small superior vagus ganglion / MGI
- cyanosis / MGI
- poor circulation / MGI
- irregular heartbeat / MGI
- absent vitelline blood vessels / MGI
- hemorrhage / MGI
- respiratory failure / MGI
- prenatal lethality / MGI
- abnormal blood circulation / MGI
- no abnormal phenotype detected / MGI
- abnormal myocardial trabeculae morphology / MGI
- abnormal cochlear ganglion morphology / MGI
- abnormal neural crest cell migration / MGI
- abnormal heart atrium morphology / MGI
- dilated heart atrium / MGI
- abnormal vitelline vasculature morphology / MGI
- kinked neural tube / MGI
- nervous system phenotype / MGI
- abnormal ventral spinal root morphology / MGI
- decreased Schwann cell precursor number / MGI
- decreased neuronal precursor cell number / MGI
- cardiovascular system phenotype / MGI
- reproductive system phenotype / MGI
- abnormal paravertebral ganglion morphology / MGI
- abnormal atrium myocardium morphology / MGI
- atrioventricular block / MGI
- perinatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- abnormal phrenic nerve innervation pattern to diaphragm / MGI