| Status | Available to order |
| EMMA ID | EM:12807 |
| Citation information | RRID:IMSR_EM:12807 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Slamf1tm1Oono Ifnar1tm1Agt/Biat |
| Alternative name | IFNAR-/- SLAM KI |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ifnar1tm1Agt, Slamf1tm1Oono |
| Gene/Transgene symbol | Ifnar1, Slamf1 |
| Provider | Roland Plesker |
| Provider affiliation | Section 4/ZT-Central Animal husbandry, Paul-Ehrlich-Institut |
| Additional owner | Yusuke Yanagi, M.D., Ph.D., Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan |
| Genetic information | Exon 2 encoding the V domain of mouse Slamf1 (Slam) gene replaced by human SLAM (Ohno S. et al., J Virol., 2007). Murine Ifnar1 gene targeted by germline transmission of disrupted allele (Müller U. et al., Science, 1994). |
| Phenotypic information | Homozygous:IFNAR knock-out: abnormal lymphopoiesis, increased susceptibility to viral infection. SLAM knock-in: increased susceptibility of lymphocytic cells to Measles virus.Heterozygous:IFNAR knock-out: none SLAM knock-in: increased susceptibility of lymphocytic cells to Measles virus. |
| Breeding history | Bred to homozygosity. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous B6.129-Slamf1tm1Oono Ifnar1tm1Agt males, homozygous B6.129-Slamf1tm1Oono Ifnar1tm1Agt females |
| Breeding at archiving centre | Sent animals were rederived to the SPF area (barrier) and a colony was built. This colony was used for Speed Cryo IVF and embryo freezing (slow) of double homozygous embryos. |
| Stage of embryos | 2-cell |
