C57BL/6NTac-Abcb4em1(IMPC)H/H

Status

Available to order

EMMA IDEM:12801
International strain nameC57BL/6NTac-Abcb4em1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolAbcb4em1(IMPC)H
Gene/Transgene symbolAbcb4

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased circulating HDL cholesterol level / IMPC
  • increased leukocyte cell number / IMPC
  • increased neutrophil cell number / IMPC
  • increased monocyte cell number / IMPC
  • increased basophil cell number / IMPC
  • decreased hemoglobin content / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased spleen weight / IMPC
  • increased lymphocyte cell number / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased circulating bilirubin level / IMPC
  • thrombocytosis / IMPC
  • increased circulating creatinine level / IMPC
  • decreased circulating glucose level / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased circulating potassium level / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • increased circulating amylase level / IMPC
  • increased red blood cell distribution width / IMPC
IMPC phenotypes (gene matching)
  • increased startle reflex / IMPC
  • increased neutrophil cell number / IMPC
  • increased spleen weight / IMPC
  • increased circulating bilirubin level / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased locomotor activity / IMPC
  • increased lymphocyte cell number / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • increased circulating creatinine level / IMPC
  • increased circulating amylase level / IMPC
  • increased leukocyte cell number / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased basophil cell number / IMPC
  • decreased circulating glucose level / IMPC
  • increased monocyte cell number / IMPC
  • decreased hemoglobin content / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating potassium level / IMPC
  • thrombocytosis / IMPC
  • decreased mean corpuscular hemoglobin / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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