IMPC phenotypes (gene matching)
C.Cg-Sema4dtm1Kik/Cnrm
| Status | Available to order |
| EMMA ID | EM:12799 |
| International strain name | C.Cg-Sema4dtm1Kik/Cnrm |
| Alternative name | Sema4D - KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Sema4dtm1Kik |
| Gene/Transgene symbol | Sema4d |
Information from provider
| Provider | Luca Tamagnone |
| Provider affiliation | Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore |
| Additional owner | Dr. Atsushi Kumanogoh, Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Graduate School of Medicine, Osaka University, Japan |
| Genetic information | Sema4d gene inactivation by targeted insertion of neo cassette in the first coding exon. |
| Phenotypic information | Homozygous:The strain does show minor developmental defects and especially relevant immunological and cancer phenotypes (reported in literature, e.g. Shi et al., 2000; Sierra et al., 2008). However, further studies are warranted. Especially, the strain should be crossed with other genetically modified mouse models with cancer or immune deficiency-related phenotypes, as well as with mutants of other class 4 semaphorins, in order to take into account redundant activities (as recently shown for members of this subfamily, Xia et al., 2015).Heterozygous:The heterozygous mice do not show any phenotype. |
| Breeding history | |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice.;Shi W, Kumanogoh A, Watanabe C, Uchida J, Wang X, Yasui T, Yukawa K, Ikawa M, Okabe M, Parnes J R, Yoshida K, Kikutani H, ;2000;Immunity;13;633-42; 11114376