IMPC phenotypes (gene matching)
C.Cg-Sema4dtm1Kik/Cnrm
| Status | Available to order |
| EMMA ID | EM:12799 |
| Citation information | RRID:IMSR_EM:12799 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C.Cg-Sema4dtm1Kik/Cnrm |
| Alternative name | Sema4D - KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Sema4dtm1Kik |
| Gene/Transgene symbol | Sema4d |
Information from provider
| Provider | Luca Tamagnone |
| Provider affiliation | Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore |
| Additional owner | Dr. Atsushi Kumanogoh, Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Graduate School of Medicine, Osaka University, Japan |
| Genetic information | Sema4d gene inactivation by targeted insertion of neo cassette in the first coding exon. |
| Phenotypic information | Homozygous:The strain does show minor developmental defects and especially relevant immunological and cancer phenotypes (reported in literature, e.g. Shi et al., 2000; Sierra et al., 2008). However, further studies are warranted. Especially, the strain should be crossed with other genetically modified mouse models with cancer or immune deficiency-related phenotypes, as well as with mutants of other class 4 semaphorins, in order to take into account redundant activities (as recently shown for members of this subfamily, Xia et al., 2015).Heterozygous:The heterozygous mice do not show any phenotype. |
| Breeding history | |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice.;Shi W, Kumanogoh A, Watanabe C, Uchida J, Wang X, Yasui T, Yukawa K, Ikawa M, Okabe M, Parnes J R, Yoshida K, Kikutani H, ;2000;Immunity;13;633-42; 11114376