- abnormal heart morphology / IMPC
- enlarged heart / IMPC
- abnormal spleen morphology / IMPC
- abnormal testis morphology / IMPC
- small testis / IMPC
- small seminal vesicle / IMPC
- abnormal seminal vesicle morphology / IMPC
- decreased lean body mass / IMPC
- abnormal auditory brainstem response / IMPC
- increased prepulse inhibition / IMPC
- decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
C57BL/6NCrl-Cd27em1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:12794 |
Citation information | RRID:IMSR_EM:12794 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6NCrl-Cd27em1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Cd27em1(IMPC)Ccpcz |
Gene/Transgene symbol | Cd27 |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Combined immunodeficiency due to CD27 deficiency / Orphanet_238505
IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
- abnormal spleen morphology / IMPC
- abnormal testis morphology / IMPC
- decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- enlarged heart / IMPC
- abnormal auditory brainstem response / IMPC
- small testis / IMPC
- small seminal vesicle / IMPC
- increased prepulse inhibition / IMPC
- decreased lean body mass / IMPC
- abnormal seminal vesicle morphology / IMPC
- abnormal heart morphology / IMPC
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