C57BL/6NCrl-Irak4em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:12792
International strain nameC57BL/6NCrl-Irak4em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolIrak4em1(IMPC)Ccpcz
Gene/Transgene symbolIrak4

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency / Orphanet_70592
MGI phenotypes (gene matching)
  • increased susceptibility to bacterial infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal cytokine secretion / MGI
  • decreased acute inflammation / MGI
  • decreased B cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal cell physiology / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-alpha secretion / MGI
  • decreased interferon-beta secretion / MGI
  • decreased circulating interferon-gamma level / MGI
  • decreased circulating interleukin-1 level / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased interleukin-12b secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal cytokine level / MGI
  • abnormal chemokine secretion / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • abnormal NK cell physiology / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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