- abnormal stomach morphology / MGI
- abnormal rectum morphology / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- intestinal ulcer / MGI
- abnormal liver morphology / MGI
- abnormal mammary gland development / MGI
- enlarged lymph nodes / MGI
- abnormal vagina morphology / MGI
- abnormal lung morphology / MGI
- abnormal body weight / MGI
- decreased body weight / MGI
- weight loss / MGI
- abnormal conjunctiva morphology / MGI
- abnormal cornea morphology / MGI
- hepatic necrosis / MGI
- postnatal growth retardation / MGI
- impaired wound healing / MGI
- abnormal inflammatory response / MGI
- eye inflammation / MGI
- conjunctivitis / MGI
- abnormal lactation / MGI
- reduced female fertility / MGI
- premature death / MGI
- abnormal larynx morphology / MGI
- abnormal trachea morphology / MGI
- abnormal blood coagulation / MGI
- colitis / MGI
- enlarged kidney / MGI
- duodenal ulcer / MGI
- gastric ulcer / MGI
- gastrointestinal ulcer / MGI
- proctitis / MGI
- liver fibrosis / MGI
- decreased susceptibility to induced choroidal neovascularization / MGI
- decreased tumor growth/size / MGI
- abnormal nervous system physiology / MGI
- abnormal microglial cell physiology / MGI
- increased hepatocyte proliferation / MGI
- abnormal conjunctival epithelium morphology / MGI
- esophageal ulcer / MGI
- perianal ulcer / MGI
- abnormal thrombosis / MGI
- cachexia / MGI
- abnormal corneal stroma morphology / MGI
- cardiovascular system phenotype / MGI
- corneal vascularization / MGI
- decreased angiogenesis / MGI
- abnormal corneal epithelium morphology / MGI
- pulmonary fibrosis / MGI
- venoocclusion / MGI
- ectropion / MGI
- eye hemorrhage / MGI
- abnormal mammary gland growth during lactation / MGI
- abnormal involution of the mammary gland / MGI
- decreased susceptibility to neuronal excitotoxicity / MGI
- abnormal mammary gland connective tissue morphology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- abnormal acute phase protein level / MGI
- lactation failure / MGI
- abnormal kidney thrombosis / MGI
- increased circulating fibrinogen level / MGI
- absent corneal epithelium / MGI
C57BL/6NCrl-Plgem1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:12790 |
International strain name | C57BL/6NCrl-Plgem1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Plgem1(IMPC)Ccpcz |
Gene/Transgene symbol | Plg |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- PLG-related hereditary angioedema with normal C1Inh / Orphanet_537072
- Hypoplasminogenemia / Orphanet_722
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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