strain-details - INFRAFRONTIER

Information from provider

Status	Under development - register interest
EMMA ID	EM:12774
International strain name	C57BL/6NCrl-Card11^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Card11^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Card11

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Disease and phenotype information

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

Orphanet associated rare diseases, based on orthologous gene matching

Severe combined immunodeficiency due to CARD11 deficiency / Orphanet_357237
BENTA disease / Orphanet_464336

IMPC phenotypes (allele matching)

increased leukocyte cell number / IMPC
abnormal spleen morphology / IMPC
small spleen / IMPC
abnormal thymus morphology / IMPC
enlarged thymus / IMPC
abnormal uterus morphology / IMPC
abnormal testis morphology / IMPC
small testis / IMPC
decreased locomotor activity / IMPC
decreased circulating alkaline phosphatase level / IMPC
decreased spleen weight / IMPC
increased lymphocyte cell number / IMPC
increased T cell number / IMPC
increased CD4-positive, alpha-beta T cell number / IMPC
increased CD8-positive, alpha-beta T cell number / IMPC
hydrometra / IMPC
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
increased CD8-positive, naive alpha-beta T cell number / IMPC
increased T-helper cell number / IMPC
decreased effector memory T-helper cell number / IMPC
increased freezing behavior / IMPC

IMPC phenotypes (gene matching)

small spleen / IMPC
abnormal spleen morphology / IMPC
increased T cell number / IMPC
small testis / IMPC
abnormal testis morphology / IMPC
decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
abnormal thymus morphology / IMPC
increased T-helper cell number / IMPC
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
decreased spleen weight / IMPC
decreased effector memory T-helper cell number / IMPC
increased freezing behavior / IMPC
increased CD4-positive, alpha-beta T cell number / IMPC
increased CD8-positive, naive alpha-beta T cell number / IMPC
increased CD8-positive, alpha-beta T cell number / IMPC
enlarged thymus / IMPC
increased lymphocyte cell number / IMPC
decreased locomotor activity / IMPC
increased leukocyte cell number / IMPC
hydrometra / IMPC
abnormal uterus morphology / IMPC
decreased circulating alkaline phosphatase level / IMPC

MGI phenotypes (gene matching)

spleen hyperplasia / MGI
dermatitis / MGI
abnormal immune system physiology / MGI
decreased IgG level / MGI
decreased IgM level / MGI
decreased IgA level / MGI
abnormal T cell activation / MGI
increased inflammatory response / MGI
lung inflammation / MGI
abnormal B cell differentiation / MGI
abnormal T cell differentiation / MGI
decreased airway responsiveness / MGI
abnormal double-negative T cell morphology / MGI
abnormal B cell physiology / MGI
decreased immunoglobulin level / MGI
increased immunoglobulin level / MGI
decreased IgE level / MGI
increased IgE level / MGI
abnormal lymphocyte morphology / MGI
abnormal cytokine secretion / MGI
erythroderma / MGI
decreased regulatory T cell number / MGI
increased B-1 B cell number / MGI
decreased B-1 B cell number / MGI
abnormal cytotoxic T cell physiology / MGI
decreased B cell proliferation / MGI
abnormal T cell proliferation / MGI
decreased T cell proliferation / MGI
abnormal B cell proliferation / MGI
immune system phenotype / MGI
decreased NK T cell number / MGI
decreased NK cell number / MGI
decreased memory T cell number / MGI
increased CD4-positive, alpha beta T cell number / MGI
increased CD8-positive, alpha-beta T cell number / MGI
abnormal T-helper 2 cell differentiation / MGI
lymph node hyperplasia / MGI
increased B-1a cell number / MGI
decreased B-1a cell number / MGI
increased B-1b cell number / MGI
absent B-1a cells / MGI
decreased mature B cell number / MGI
absent immature B cells / MGI
decreased gamma-delta T cell number / MGI
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology / MGI
decreased IgG1 level / MGI
decreased IgG2a level / MGI
decreased IgG2b level / MGI
decreased IgG3 level / MGI
decreased interferon-gamma secretion / MGI
decreased circulating interleukin-4 level / MGI
decreased circulating interleukin-5 level / MGI
abnormal interleukin-2 secretion / MGI
decreased interleukin-2 secretion / MGI
decreased IgG2c level / MGI
abnormal NK cell physiology / MGI
impaired humoral immune response / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

C57BL/6NCrl-Card11^{em1(IMPC)Ccpcz}/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Card11em1(IMPC)Ccpcz/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Card11^{em1(IMPC)Ccpcz}/Ph