C57BL/6NCrl-Card11em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:12774
Citation informationRRID:IMSR_EM:12774 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NCrl-Card11em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolCard11em1(IMPC)Ccpcz
Gene/Transgene symbolCard11

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased leukocyte cell number / IMPC
  • abnormal spleen morphology / IMPC
  • small spleen / IMPC
  • abnormal thymus morphology / IMPC
  • enlarged thymus / IMPC
  • abnormal uterus morphology / IMPC
  • abnormal testis morphology / IMPC
  • small testis / IMPC
  • decreased locomotor activity / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • decreased spleen weight / IMPC
  • increased lymphocyte cell number / IMPC
  • increased T cell number / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • hydrometra / IMPC
  • decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • increased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased T-helper cell number / IMPC
  • decreased effector memory T-helper cell number / IMPC
  • increased freezing behavior / IMPC
IMPC phenotypes (gene matching)
  • small spleen / IMPC
  • abnormal spleen morphology / IMPC
  • increased T cell number / IMPC
  • small testis / IMPC
  • abnormal testis morphology / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • abnormal thymus morphology / IMPC
  • increased T-helper cell number / IMPC
  • decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased spleen weight / IMPC
  • decreased effector memory T-helper cell number / IMPC
  • increased freezing behavior / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • increased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • enlarged thymus / IMPC
  • increased lymphocyte cell number / IMPC
  • decreased locomotor activity / IMPC
  • increased leukocyte cell number / IMPC
  • hydrometra / IMPC
  • abnormal uterus morphology / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
MGI phenotypes (gene matching)
  • spleen hyperplasia / MGI
  • dermatitis / MGI
  • abnormal immune system physiology / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • decreased IgA level / MGI
  • abnormal T cell activation / MGI
  • increased inflammatory response / MGI
  • lung inflammation / MGI
  • abnormal B cell differentiation / MGI
  • abnormal T cell differentiation / MGI
  • decreased airway responsiveness / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal B cell physiology / MGI
  • decreased immunoglobulin level / MGI
  • increased immunoglobulin level / MGI
  • decreased IgE level / MGI
  • increased IgE level / MGI
  • abnormal lymphocyte morphology / MGI
  • abnormal cytokine secretion / MGI
  • erythroderma / MGI
  • decreased regulatory T cell number / MGI
  • increased B-1 B cell number / MGI
  • decreased B-1 B cell number / MGI
  • abnormal cytotoxic T cell physiology / MGI
  • decreased B cell proliferation / MGI
  • abnormal T cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • abnormal B cell proliferation / MGI
  • immune system phenotype / MGI
  • decreased NK T cell number / MGI
  • decreased NK cell number / MGI
  • decreased memory T cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • abnormal T-helper 2 cell differentiation / MGI
  • lymph node hyperplasia / MGI
  • increased B-1a cell number / MGI
  • decreased B-1a cell number / MGI
  • increased B-1b cell number / MGI
  • absent B-1a cells / MGI
  • decreased mature B cell number / MGI
  • absent immature B cells / MGI
  • decreased gamma-delta T cell number / MGI
  • abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • decreased interferon-gamma secretion / MGI
  • decreased circulating interleukin-4 level / MGI
  • decreased circulating interleukin-5 level / MGI
  • abnormal interleukin-2 secretion / MGI
  • decreased interleukin-2 secretion / MGI
  • decreased IgG2c level / MGI
  • abnormal NK cell physiology / MGI
  • impaired humoral immune response / MGI

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Register interest

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    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
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