C57BL/6N-Odad3^{tm1b(EUCOMM)Hmgu}/Cnrm

Status	Available to order
EMMA ID	EM:12746
International strain name	C57BL/6N-Odad3^{tm1b(EUCOMM)Hmgu}/Cnrm
Alternative name	HEPD0634_2_D03
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Odad3^{tm1b(EUCOMM)Hmgu}
Gene/Transgene symbol	Odad3
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	CNR, Consiglio Nazionale delle Ricerche
Provider affiliation	EMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0634_2_D03. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sortm1(ACTB-cre,-EGFP)Ics (MGI:5285392)). Click here for more information on EUCOMM final vectors.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia.;Chiani Francesco, Orsini Tiziana, Gambadoro Alessia, Pasquini Miriam, Putti Sabrina, Cirilli Maurizio, Ermakova Olga, Tocchini-Valentini Glauco P, ;2019;Disease models & mechanisms;12;; 31383820 The Odad3 Gene Is Necessary for Spermatozoa Development and Male Fertility in Mice.;Pasquini Miriam, Chiani Francesco, Gambadoro Alessia, Di Pietro Chiara, Paoletti Renata, Orsini Tiziana, Putti Sabrina, Scavizzi Ferdinando, La Sala Gina, Ermakova Olga, ;2024;Cells;13;; 38920681

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (allele matching)

decreased bone mineral density / IMPC
abnormal bone structure / IMPC
impaired glucose tolerance / IMPC
preweaning lethality, incomplete penetrance / IMPC

IMPC phenotypes (gene matching)

decreased bone mineral density / IMPC
abnormal bone structure / IMPC
preweaning lethality, incomplete penetrance / IMPC
impaired glucose tolerance / IMPC

Literature references

Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia.;Chiani Francesco, Orsini Tiziana, Gambadoro Alessia, Pasquini Miriam, Putti Sabrina, Cirilli Maurizio, Ermakova Olga, Tocchini-Valentini Glauco P, ;2019;Disease models & mechanisms;12;; 31383820
The Odad3 Gene Is Necessary for Spermatozoa Development and Male Fertility in Mice.;Pasquini Miriam, Chiani Francesco, Gambadoro Alessia, Di Pietro Chiara, Paoletti Renata, Orsini Tiziana, Putti Sabrina, Scavizzi Ferdinando, La Sala Gina, Ermakova Olga, ;2024;Cells;13;; 38920681

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Odad3tm1b(EUCOMM)Hmgu/Cnrm