C57BL/6NCrl-Ahrem1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:12733
International strain nameC57BL/6NCrl-Ahrem1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolAhrem1(IMPC)Ccpcz
Gene/Transgene symbolAhr

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • extramedullary hematopoiesis / MGI
  • abnormal heart morphology / MGI
  • enlarged heart / MGI
  • abnormal coat/ hair morphology / MGI
  • folliculitis / MGI
  • abnormal hair follicle morphology / MGI
  • abnormal auchene hair morphology / MGI
  • alopecia / MGI
  • rectal prolapse / MGI
  • abnormal colon morphology / MGI
  • abnormal kidney blood vessel morphology / MGI
  • abnormal urinary bladder morphology / MGI
  • abnormal urinary bladder urothelium morphology / MGI
  • abnormal liver morphology / MGI
  • small liver / MGI
  • pale liver / MGI
  • abnormal hepatocyte morphology / MGI
  • abnormal liver physiology / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • small prostate gland anterior lobe / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • small spleen / MGI
  • spleen hypoplasia / MGI
  • abnormal uterus morphology / MGI
  • small ovary / MGI
  • abnormal ovarian folliculogenesis / MGI
  • seminiferous tubule degeneration / MGI
  • abnormal skin condition / MGI
  • scaly skin / MGI
  • thick skin / MGI
  • spontaneous skin ulceration / MGI
  • skin lesions / MGI
  • abnormal epidermal layer morphology / MGI
  • increased body weight / MGI
  • decreased body weight / MGI
  • weight loss / MGI
  • disorganized retinal layers / MGI
  • abnormal blood vessel morphology / MGI
  • chronic diarrhea / MGI
  • postnatal growth retardation / MGI
  • abnormal immune system physiology / MGI
  • increased inflammatory response / MGI
  • heart inflammation / MGI
  • abnormal atrial thrombosis / MGI
  • lung inflammation / MGI
  • acanthosis / MGI
  • reduced female fertility / MGI
  • abnormal ovulation / MGI
  • decreased litter size / MGI
  • premature death / MGI
  • decreased germ cell number / MGI
  • abnormal spleen red pulp morphology / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal macrophage physiology / MGI
  • hepatic steatosis / MGI
  • abnormal cauda epididymis morphology / MGI
  • decreased corpora lutea number / MGI
  • colitis / MGI
  • increased heart weight / MGI
  • vascular smooth muscle hypertrophy / MGI
  • abnormal cytokine secretion / MGI
  • no phenotypic analysis / MGI
  • cardiac fibrosis / MGI
  • bile duct inflammation / MGI
  • gastric polyps / MGI
  • increased liver adenoma incidence / MGI
  • liver fibrosis / MGI
  • decreased liver weight / MGI
  • abnormal keratinocyte physiology / MGI
  • abnormal ovary physiology / MGI
  • nervous system phenotype / MGI
  • abnormal hair shaft morphology / MGI
  • pulmonary edema / MGI
  • patent ductus venosus / MGI
  • abnormal coronary artery morphology / MGI
  • abnormal spermiation / MGI
  • increased incidence of tumors by chemical induction / MGI
  • decreased testis weight / MGI
  • decreased ovary weight / MGI
  • decreased seminal vesicle weight / MGI
  • decreased epididymis weight / MGI
  • increased spleen weight / MGI
  • abnormal thrombosis / MGI
  • liver hyperplasia / MGI
  • increased susceptibility to injury / MGI
  • abnormal Langerhans cell physiology / MGI
  • renal/urinary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • reproductive system phenotype / MGI
  • skeleton phenotype / MGI
  • abnormal circulating hormone level / MGI
  • teratozoospermia / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal Langerhans cell morphology / MGI
  • abnormal male germ cell apoptosis / MGI
  • decreased spleen white pulp amount / MGI
  • decreased spleen germinal center size / MGI
  • abnormal cytokine level / MGI
  • abnormal chemokine level / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • abnormal xenobiotic pharmacokinetics / MGI
  • abnormal liver sinusoid morphology / MGI
  • abnormal sperm head morphology / MGI
  • coiled sperm flagellum / MGI
  • abnormal primordial ovarian follicle morphology / MGI
  • increased urinary bladder carcinoma incidence / MGI
  • hypergranulosis / MGI
  • abnormal optokinetic reflex / MGI
  • urinary bladder inflammation / MGI
  • decreased fertilization frequency / MGI
  • abnormal superovulation / MGI
  • small prostate gland dorsolateral lobe / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • increased urine uric acid level / MGI
  • increased hepatoma incidence / MGI
  • abnormal stomach pyloric region morphology / MGI
  • pulmonary alveolar edema / MGI
  • abnormal horizontal vestibuloocular reflex / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • cystolithiasis / MGI
  • abnormal seminiferous tubule epithelium morphology / MGI
  • urinary bladder fibrosis / MGI
  • abnormal urinary bladder blood vessel morphology / MGI
  • persistent hyaloid artery / MGI
  • multinucleated giant male germ cells / MGI
  • dilated piliary canal / MGI

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Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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