- extramedullary hematopoiesis / MGI
- abnormal heart morphology / MGI
- enlarged heart / MGI
- abnormal coat/ hair morphology / MGI
- folliculitis / MGI
- abnormal hair follicle morphology / MGI
- abnormal auchene hair morphology / MGI
- alopecia / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- abnormal kidney blood vessel morphology / MGI
- abnormal urinary bladder morphology / MGI
- abnormal urinary bladder urothelium morphology / MGI
- abnormal liver morphology / MGI
- small liver / MGI
- pale liver / MGI
- abnormal hepatocyte morphology / MGI
- abnormal liver physiology / MGI
- abnormal branching of the mammary ductal tree / MGI
- small prostate gland anterior lobe / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- abnormal uterus morphology / MGI
- small ovary / MGI
- abnormal ovarian folliculogenesis / MGI
- seminiferous tubule degeneration / MGI
- abnormal skin condition / MGI
- scaly skin / MGI
- thick skin / MGI
- spontaneous skin ulceration / MGI
- skin lesions / MGI
- abnormal epidermal layer morphology / MGI
- increased body weight / MGI
- decreased body weight / MGI
- weight loss / MGI
- disorganized retinal layers / MGI
- abnormal blood vessel morphology / MGI
- chronic diarrhea / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- increased inflammatory response / MGI
- heart inflammation / MGI
- abnormal atrial thrombosis / MGI
- lung inflammation / MGI
- acanthosis / MGI
- reduced female fertility / MGI
- abnormal ovulation / MGI
- decreased litter size / MGI
- premature death / MGI
- decreased germ cell number / MGI
- abnormal spleen red pulp morphology / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- hepatic steatosis / MGI
- abnormal cauda epididymis morphology / MGI
- decreased corpora lutea number / MGI
- colitis / MGI
- increased heart weight / MGI
- vascular smooth muscle hypertrophy / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- cardiac fibrosis / MGI
- bile duct inflammation / MGI
- gastric polyps / MGI
- increased liver adenoma incidence / MGI
- liver fibrosis / MGI
- decreased liver weight / MGI
- abnormal keratinocyte physiology / MGI
- abnormal ovary physiology / MGI
- nervous system phenotype / MGI
- abnormal hair shaft morphology / MGI
- pulmonary edema / MGI
- patent ductus venosus / MGI
- abnormal coronary artery morphology / MGI
- abnormal spermiation / MGI
- increased incidence of tumors by chemical induction / MGI
- decreased testis weight / MGI
- decreased ovary weight / MGI
- decreased seminal vesicle weight / MGI
- decreased epididymis weight / MGI
- increased spleen weight / MGI
- abnormal thrombosis / MGI
- liver hyperplasia / MGI
- increased susceptibility to injury / MGI
- abnormal Langerhans cell physiology / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- abnormal circulating hormone level / MGI
- teratozoospermia / MGI
- abnormal enzyme/coenzyme activity / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal Langerhans cell morphology / MGI
- abnormal male germ cell apoptosis / MGI
- decreased spleen white pulp amount / MGI
- decreased spleen germinal center size / MGI
- abnormal cytokine level / MGI
- abnormal chemokine level / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- abnormal xenobiotic pharmacokinetics / MGI
- abnormal liver sinusoid morphology / MGI
- abnormal sperm head morphology / MGI
- coiled sperm flagellum / MGI
- abnormal primordial ovarian follicle morphology / MGI
- increased urinary bladder carcinoma incidence / MGI
- hypergranulosis / MGI
- abnormal optokinetic reflex / MGI
- urinary bladder inflammation / MGI
- decreased fertilization frequency / MGI
- abnormal superovulation / MGI
- small prostate gland dorsolateral lobe / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased urine uric acid level / MGI
- increased hepatoma incidence / MGI
- abnormal stomach pyloric region morphology / MGI
- pulmonary alveolar edema / MGI
- abnormal horizontal vestibuloocular reflex / MGI
- postnatal lethality, incomplete penetrance / MGI
- cystolithiasis / MGI
- abnormal seminiferous tubule epithelium morphology / MGI
- urinary bladder fibrosis / MGI
- abnormal urinary bladder blood vessel morphology / MGI
- persistent hyaloid artery / MGI
- multinucleated giant male germ cells / MGI
- dilated piliary canal / MGI
C57BL/6NCrl-Ahrem1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:12733 |
International strain name | C57BL/6NCrl-Ahrem1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Ahrem1(IMPC)Ccpcz |
Gene/Transgene symbol | Ahr |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Retinitis pigmentosa / Orphanet_791
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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