C57BL/6NCrl-Camk4em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:12725
International strain nameC57BL/6NCrl-Camk4em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolCamk4em1(IMPC)Ccpcz
Gene/Transgene symbolCamk4

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal heart morphology / IMPC
  • enlarged heart / IMPC
  • abnormal spleen morphology / IMPC
  • small spleen / IMPC
  • abnormal thymus morphology / IMPC
  • enlarged thymus / IMPC
  • abnormal testis morphology / IMPC
  • enlarged testis / IMPC
  • abnormal tooth morphology / IMPC
  • decreased spleen weight / IMPC
IMPC phenotypes (gene matching)
  • abnormal tooth morphology / IMPC
  • abnormal heart morphology / IMPC
  • small spleen / IMPC
  • enlarged thymus / IMPC
  • enlarged heart / IMPC
  • decreased spleen weight / IMPC
  • abnormal spleen morphology / IMPC
  • abnormal thymus morphology / IMPC
  • enlarged testis / IMPC
  • abnormal testis morphology / IMPC
MGI phenotypes (gene matching)
  • increased bone mineral density / MGI
  • tremors / MGI
  • abnormal Purkinje cell morphology / MGI
  • decreased Purkinje cell number / MGI
  • abnormal female reproductive system morphology / MGI
  • abnormal ovarian follicle morphology / MGI
  • absent corpus luteum / MGI
  • abnormal male reproductive system morphology / MGI
  • seminiferous tubule degeneration / MGI
  • arrest of spermatogenesis / MGI
  • decreased body weight / MGI
  • decreased anxiety-related response / MGI
  • ataxia / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • reduced long term depression / MGI
  • limb grasping / MGI
  • abnormal reproductive system physiology / MGI
  • reduced female fertility / MGI
  • male infertility / MGI
  • abnormal gametogenesis / MGI
  • abnormal spermiogenesis / MGI
  • decreased litter size / MGI
  • decreased chemically-elicited antinociception / MGI
  • abnormal learning/memory/conditioning / MGI
  • premature death / MGI
  • abnormal reproductive system morphology / MGI
  • no abnormal phenotype detected / MGI
  • oligozoospermia / MGI
  • decreased vertical activity / MGI
  • abnormal excitatory postsynaptic currents / MGI
  • abnormal synaptic depression / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • abnormal bone remodeling / MGI
  • abnormal locomotor activation / MGI
  • nervous system phenotype / MGI
  • decreased testis weight / MGI
  • decreased male germ cell number / MGI
  • abnormal behavior / MGI
  • decreased osteoclast cell number / MGI
  • homeostasis/metabolism phenotype / MGI
  • behavior/neurological phenotype / MGI
  • teratozoospermia / MGI
  • abnormal spermatid morphology / MGI
  • abnormal osteoclast differentiation / MGI
  • abnormal Purkinje cell dendrite morphology / MGI
  • anovulation / MGI
  • abnormal sperm flagellum morphology / MGI
  • abnormal sperm head morphology / MGI
  • polyovular ovarian follicle / MGI
  • impaired contextual conditioning behavior / MGI
  • impaired cued conditioning behavior / MGI
  • impaired conditioned place preference behavior / MGI
  • increased bone volume / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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