IMPC phenotypes (gene matching)
C57BL/6-Ccr2tm1(cre/ERT2,mKate2)Arte/Orl
| Status | Available to order |
| EMMA ID | EM:12698 |
| International strain name | C57BL/6-Ccr2tm1(cre/ERT2,mKate2)Arte/Orl |
| Alternative name | C57BL/6NTac-Ccr2tm2982(T2A-Cre/ESR1-T2A-mKate2)Art |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Ccr2tm1(cre/ERT2,mKate2)Arte |
| Gene/Transgene symbol | Ccr2 |
Information from provider
| Provider | Burkhard Becher |
| Provider affiliation | University of Zurich |
| Genetic information | Ccr2-CreERT2-mKate2: This strain contains the ORF of CreERT2 and mKate2 knocked into the endogenous murine Ccr2 locus. Ensembl gene ID: ENSMUSG00000049103 |
| Phenotypic information | Homozygous:Animals are viable and fertile, no phenotypic difference to C57BL/6 mice.Heterozygous:Animals are viable and fertile, no phenotypic difference to C57BL/6 mice. |
| Breeding history | The mice have been bred in our facility for many generations and more than 100 animals were born. Heterozygous and homozygous mice are viable and fertile. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6NTac |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal trabecular bone morphology / MGI
- decreased neutrophil cell number / MGI
- decreased monocyte cell number / MGI
- altered response to myocardial infarction / MGI
- enlarged liver / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- weight loss / MGI
- retinal degeneration / MGI
- abnormal osteoclast physiology / MGI
- hepatic necrosis / MGI
- multifocal hepatic necrosis / MGI
- liver inflammation / MGI
- decreased inflammatory response / MGI
- abnormal glucose homeostasis / MGI
- abnormal lipid homeostasis / MGI
- decreased airway responsiveness / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal leukocyte physiology / MGI
- abnormal macrophage morphology / MGI
- increased IgG level / MGI
- alcohol aversion / MGI
- abnormal monocyte morphology / MGI
- abnormal immune serum protein physiology / MGI
- abnormal conditioned taste aversion behavior / MGI
- increased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- abnormal leukocyte migration / MGI
- decreased tumor growth/size / MGI
- increased alcohol consumption / MGI
- decreased alcohol consumption / MGI
- abnormal leukocyte adhesion / MGI
- abnormal microglial cell physiology / MGI
- impaired macrophage chemotaxis / MGI
- decreased macrophage cell number / MGI
- increased hepatocyte apoptosis / MGI
- liver hemorrhage / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal vascular wound healing / MGI
- abnormal osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- abnormal wound healing / MGI
- diarrhea / MGI
- decreased acute inflammation / MGI
- decreased T cell proliferation / MGI
- abnormal optic choroid morphology / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal Bruch membrane morphology / MGI
- abnormal cholesterol homeostasis / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal podocyte morphology / MGI
- abnormal Langerhans cell physiology / MGI
- immune system phenotype / MGI
- choroidal neovascularization / MGI
- decreased circulating creatinine level / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- retinal deposits / MGI
- abnormal choriocapillaris morphology / MGI
- abnormal urine protein level / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased dendritic cell number / MGI
- abnormal osteoclast differentiation / MGI
- retinal photoreceptor degeneration / MGI
- retinal outer nuclear layer degeneration / MGI
- increased susceptibility to induced colitis / MGI
- decreased susceptibility to induced colitis / MGI
- increased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-2 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal chemokine secretion / MGI
- decreased common myeloid progenitor cell number / MGI
- lipofuscinosis / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased splenocyte proliferation / MGI
- increased trabecular bone thickness / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal cellular extravasation / MGI
- decreased susceptibility to bone fracture / MGI
- abnormal bone mineral density / MGI
- abnormal dendritic cell chemotaxis / MGI
- abnormal macrophage chemotaxis / MGI
- abnormal bone trabecula morphology / MGI
- increased trabecular bone volume / MGI
- increased fluid intake / MGI
- increased CD11b-high dendritic cell number / MGI
- decreased CD11b-high dendritic cell number / MGI
- impaired leukocyte tethering or rolling / MGI
Literature references
- The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.;Croxford Andrew L, Lanzinger Margit, Hartmann Felix J, Schreiner Bettina, Mair Florian, Pelczar Pawel, Clausen Björn E, Jung Steffen, Greter Melanie, Becher Burkhard, ;2015;Immunity;43;502-14; 26341401