IMPC phenotypes (gene matching)
C57BL/6-Ccr2tm1(cre/ERT2,mKate2)Arte/Orl
| Status | Available to order |
| EMMA ID | EM:12698 |
| Citation information | RRID:IMSR_EM:12698 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Ccr2tm1(cre/ERT2,mKate2)Arte/Orl |
| Alternative name | C57BL/6NTac-Ccr2tm2982(T2A-Cre/ESR1-T2A-mKate2)Art |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Ccr2tm1(cre/ERT2,mKate2)Arte |
| Gene/Transgene symbol | Ccr2 |
Information from provider
| Provider | Burkhard Becher |
| Provider affiliation | University of Zurich |
| Genetic information | Ccr2-CreERT2-mKate2: This strain contains the ORF of CreERT2 and mKate2 knocked into the endogenous murine Ccr2 locus. Ensembl gene ID: ENSMUSG00000049103 |
| Phenotypic information | Homozygous:Animals are viable and fertile, no phenotypic difference to C57BL/6 mice.Heterozygous:Animals are viable and fertile, no phenotypic difference to C57BL/6 mice. |
| Breeding history | The mice have been bred in our facility for many generations and more than 100 animals were born. Heterozygous and homozygous mice are viable and fertile. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6NTac males |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal trabecular bone morphology / MGI
- decreased neutrophil cell number / MGI
- decreased monocyte cell number / MGI
- altered response to myocardial infarction / MGI
- enlarged liver / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- weight loss / MGI
- retinal degeneration / MGI
- abnormal osteoclast physiology / MGI
- hepatic necrosis / MGI
- multifocal hepatic necrosis / MGI
- liver inflammation / MGI
- decreased inflammatory response / MGI
- abnormal glucose homeostasis / MGI
- abnormal lipid homeostasis / MGI
- decreased airway responsiveness / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal leukocyte physiology / MGI
- abnormal macrophage morphology / MGI
- increased IgG level / MGI
- alcohol aversion / MGI
- abnormal monocyte morphology / MGI
- abnormal immune serum protein physiology / MGI
- abnormal conditioned taste aversion behavior / MGI
- increased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- abnormal leukocyte migration / MGI
- decreased tumor growth/size / MGI
- increased alcohol consumption / MGI
- decreased alcohol consumption / MGI
- abnormal leukocyte adhesion / MGI
- abnormal microglial cell physiology / MGI
- impaired macrophage chemotaxis / MGI
- decreased macrophage cell number / MGI
- increased hepatocyte apoptosis / MGI
- liver hemorrhage / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal vascular wound healing / MGI
- abnormal osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- abnormal wound healing / MGI
- diarrhea / MGI
- decreased acute inflammation / MGI
- decreased T cell proliferation / MGI
- abnormal optic choroid morphology / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal Bruch membrane morphology / MGI
- abnormal cholesterol homeostasis / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal podocyte morphology / MGI
- abnormal Langerhans cell physiology / MGI
- immune system phenotype / MGI
- choroidal neovascularization / MGI
- decreased circulating creatinine level / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- retinal deposits / MGI
- abnormal choriocapillaris morphology / MGI
- abnormal urine protein level / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased dendritic cell number / MGI
- abnormal osteoclast differentiation / MGI
- retinal photoreceptor degeneration / MGI
- retinal outer nuclear layer degeneration / MGI
- increased susceptibility to induced colitis / MGI
- decreased susceptibility to induced colitis / MGI
- increased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-2 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal chemokine secretion / MGI
- decreased common myeloid progenitor cell number / MGI
- lipofuscinosis / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased splenocyte proliferation / MGI
- increased trabecular bone thickness / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal cellular extravasation / MGI
- decreased susceptibility to bone fracture / MGI
- abnormal bone mineral density / MGI
- abnormal dendritic cell chemotaxis / MGI
- abnormal macrophage chemotaxis / MGI
- abnormal bone trabecula morphology / MGI
- increased trabecular bone volume / MGI
- increased fluid intake / MGI
- increased CD11b-high dendritic cell number / MGI
- decreased CD11b-high dendritic cell number / MGI
- impaired leukocyte tethering or rolling / MGI
Literature references
- The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.;Croxford Andrew L, Lanzinger Margit, Hartmann Felix J, Schreiner Bettina, Mair Florian, Pelczar Pawel, Clausen Björn E, Jung Steffen, Greter Melanie, Becher Burkhard, ;2015;Immunity;43;502-14; 26341401