C57BL/6NCrl-Klhl6em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:12696
International strain nameC57BL/6NCrl-Klhl6em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolKlhl6em1(IMPC)Ccpcz
Gene/Transgene symbolKlhl6

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • abnormal heart morphology / IMPC
  • enlarged heart / IMPC
  • abnormal spleen morphology / IMPC
  • small spleen / IMPC
  • abnormal thymus morphology / IMPC
  • enlarged thymus / IMPC
  • abnormal testis morphology / IMPC
  • small testis / IMPC
  • small seminal vesicle / IMPC
  • abnormal lung morphology / IMPC
  • abnormal pancreas morphology / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • abnormal kidney morphology / IMPC
  • abnormal inspiratory capacity / IMPC
  • enlarged kidney / IMPC
  • enlarged pancreas / IMPC
  • decreased eosinophil cell number / IMPC
  • increased T cell number / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • increased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased T-helper cell number / IMPC
  • decreased effector memory T-helper cell number / IMPC
IMPC phenotypes (gene matching)
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • abnormal testis morphology / IMPC
  • abnormal thymus morphology / IMPC
  • small seminal vesicle / IMPC
  • abnormal heart morphology / IMPC
  • abnormal spleen morphology / IMPC
  • enlarged thymus / IMPC
  • enlarged heart / IMPC
  • abnormal pancreas morphology / IMPC
  • increased T cell number / IMPC
  • abnormal lung morphology / IMPC
  • abnormal kidney morphology / IMPC
  • enlarged kidney / IMPC
  • decreased effector memory T-helper cell number / IMPC
  • abnormal inspiratory capacity / IMPC
  • decreased eosinophil cell number / IMPC
  • small spleen / IMPC
  • small testis / IMPC
  • increased T-helper cell number / IMPC
  • increased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • enlarged pancreas / IMPC
MGI phenotypes (gene matching)
  • abnormal spleen morphology / MGI
  • spleen hypoplasia / MGI
  • abnormal B cell differentiation / MGI
  • abnormal adaptive immunity / MGI
  • decreased spleen weight / MGI
  • increased T cell number / MGI
  • decreased B cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased single-positive T cell number / MGI
  • increased B-1b cell number / MGI
  • decreased follicular B cell number / MGI
  • decreased mature B cell number / MGI
  • increased immature B cell number / MGI
  • abnormal lymph node germinal center morphology / MGI
  • decreased central memory CD4-positive, alpha-beta T cell number / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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