IMPC phenotypes (allele matching)
C57BL/6NTac-Irs1em1(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:12668 |
| International strain name | C57BL/6NTac-Irs1em1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Irs1em1(IMPC)H |
| Gene/Transgene symbol | Irs1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- abnormal long bone hypertrophic chondrocyte zone / MGI
- decreased chondrocyte number / MGI
- decreased circulating HDL cholesterol level / MGI
- hypertension / MGI
- decreased cell proliferation / MGI
- abnormal femur morphology / MGI
- thin tail / MGI
- short tail / MGI
- decreased body length / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal osteoclast physiology / MGI
- abnormal lipid level / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- postnatal growth retardation / MGI
- abnormal glucose homeostasis / MGI
- increased circulating insulin level / MGI
- postnatal lethality / MGI
- premature death / MGI
- abnormal postnatal growth/weight/body size / MGI
- abnormal tail morphology / MGI
- short tibia / MGI
- abnormal bone mineralization / MGI
- abnormal bone healing / MGI
- decreased insulin secretion / MGI
- short femur / MGI
- abnormal long bone epiphyseal plate proliferative zone / MGI
- abnormal bone structure / MGI
- fetal growth retardation / MGI
- abnormal vascular wound healing / MGI
- increased osteoclast cell number / MGI
- increased osteoblast cell number / MGI
- decreased osteoblast cell number / MGI
- abnormal osteoblast physiology / MGI
- abnormal cell differentiation / MGI
- abnormal pancreatic beta cell morphology / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- skeleton phenotype / MGI
- decreased percent body fat/body weight / MGI
- decreased circulating glucose level / MGI
- decreased vasodilation / MGI
- increased systemic arterial diastolic blood pressure / MGI
- increased systemic arterial systolic blood pressure / MGI
- decreased long bone epiphyseal plate size / MGI
- impaired lipolysis / MGI
- abnormal osteoclast differentiation / MGI
- proportional dwarf / MGI
- decreased trabecular bone thickness / MGI
- decreased fetal weight / MGI
- decreased birth weight / MGI
- decreased total body fat amount / MGI
- decreased bone mineral content / MGI
- mortality/aging / MGI
- impaired osteoblast differentiation / MGI
- increased or absent threshold for auditory brainstem response / MGI
- decreased osteoblast proliferation / MGI