B6.Cg-Fbxw7tm1.1Axbe Foxm1tm1Rhc/H
| Status | Available to order |
| EMMA ID | EM:12633 |
| International strain name | B6.Cg-Fbxw7tm1.1Axbe Foxm1tm1Rhc/H |
| Alternative name | Double Floxed Fbxw7/FoxM1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Foxm1tm1Rhc, Fbxw7tm1.1Axbe |
| Gene/Transgene symbol | Foxm1, Fbxw7 |
Information from provider
| Provider | Cancer Research UK |
| Provider affiliation | Ximbio, Cancer Research UK |
| Additional owner | Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, USA |
| Genetic information | Floxed Fbxw7 gene and floxed Foxm1 gene. We have initially generated the Fbxw7 fl/fl homozygous mice (floxed Fbxw7, see EMMA strain EM:12632) and these were interbred with the Foxm1 fl/fl homozygous mice (floxed-Foxm1), both in C57BL/6 background. Foxm1 fl/fl homozygous mice were kindly gifted by Dr. RH Costa (Gastroenterology. 2007 Apr;132(4):1420-31. & Proc Natl Acad Sci U S A, 99 2002, pp. 16881–16886). Different configuration of Fbxw7 and Foxm1 genes were verified by PCR analysis. |
| Phenotypic information | Homozygous:No overt phenotype, cre recombinase required for deletion of Fbxw7 and Foxm1.Heterozygous:No overt phenotype, cre recombinase required for deletion of Fbxw7 and Foxm1. |
| Breeding history | Backcrossed onto C57BL/6J for at least 5 generations. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |