C57BL/6NCrl-Spred1em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:12627
International strain nameC57BL/6NCrl-Spred1em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolSpred1em1(IMPC)Ccpcz
Gene/Transgene symbolSpred1

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • abnormal vertebrae morphology / IMPC
  • increased neutrophil cell number / IMPC
  • abnormal heart morphology / IMPC
  • enlarged heart / IMPC
  • abnormal head morphology / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal snout morphology / IMPC
  • abnormal maxilla morphology / IMPC
  • abnormal mandible morphology / IMPC
  • abnormal spleen morphology / IMPC
  • enlarged spleen / IMPC
  • enlarged lymph nodes / IMPC
  • abnormal thymus morphology / IMPC
  • enlarged thymus / IMPC
  • tremors / IMPC
  • abnormal ovary morphology / IMPC
  • small seminal vesicle / IMPC
  • decreased body weight / IMPC
  • anophthalmia / IMPC
  • abnormal retina morphology / IMPC
  • decreased locomotor activity / IMPC
  • abnormal startle reflex / IMPC
  • hydrocephaly / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • abnormal skin morphology / IMPC
  • abnormal eye morphology / IMPC
  • abnormal tooth morphology / IMPC
  • abnormal brain morphology / IMPC
  • abnormal lymph node morphology / IMPC
  • increased thigmotaxis / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • abnormal bone structure / IMPC
  • increased kidney weight / IMPC
  • abnormal vertebral arch morphology / IMPC
  • vertebral fusion / IMPC
  • fusion of vertebral arches / IMPC
  • abnormal auditory brainstem response / IMPC
  • increased spleen weight / IMPC
  • decreased lymphocyte cell number / IMPC
  • abnormal zygomatic bone morphology / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased circulating potassium level / IMPC
  • increased NK T cell number / IMPC
  • decreased grip strength / IMPC
  • increased circulating creatine kinase level / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • abnormal skin coloration / IMPC
  • abnormal head size / IMPC
  • increased CD4-positive NK T cell number / IMPC
  • increased memory-marker CD4-positive NK T cell number / IMPC
  • increased effector memory T-helper cell number / IMPC
  • increased freezing behavior / IMPC
IMPC phenotypes (gene matching)
  • abnormal spleen morphology / IMPC
  • increased CD4-positive NK T cell number / IMPC
  • increased circulating alanine transaminase level / IMPC
  • abnormal zygomatic bone morphology / IMPC
  • abnormal brain morphology / IMPC
  • abnormal snout morphology / IMPC
  • enlarged spleen / IMPC
  • vertebral fusion / IMPC
  • increased thigmotaxis / IMPC
  • hydrocephaly / IMPC
  • abnormal thymus morphology / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • abnormal tooth morphology / IMPC
  • decreased body weight / IMPC
  • enlarged heart / IMPC
  • increased effector memory T-helper cell number / IMPC
  • increased spleen weight / IMPC
  • decreased grip strength / IMPC
  • decreased lymphocyte cell number / IMPC
  • abnormal vertebrae morphology / IMPC
  • abnormal head morphology / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • abnormal bone structure / IMPC
  • abnormal mandible morphology / IMPC
  • abnormal maxilla morphology / IMPC
  • enlarged thymus / IMPC
  • abnormal heart morphology / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • increased freezing behavior / IMPC
  • increased circulating creatine kinase level / IMPC
  • abnormal lymph node morphology / IMPC
  • abnormal auditory brainstem response / IMPC
  • increased neutrophil cell number / IMPC
  • anophthalmia / IMPC
  • abnormal startle reflex / IMPC
  • increased memory-marker CD4-positive NK T cell number / IMPC
  • tremors / IMPC
  • small seminal vesicle / IMPC
  • abnormal head size / IMPC
  • abnormal retina morphology / IMPC
  • abnormal ovary morphology / IMPC
  • fusion of vertebral arches / IMPC
  • abnormal vertebral arch morphology / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • abnormal skin morphology / IMPC
  • increased kidney weight / IMPC
  • abnormal eye morphology / IMPC
  • decreased locomotor activity / IMPC
  • increased NK T cell number / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal skin coloration / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased circulating potassium level / IMPC
  • enlarged lymph nodes / IMPC

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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