C57BL/6NCrl-Spred1^{em1(IMPC)Ccpcz}/Ph

Status	Under development - register interest
EMMA ID	EM:12627
Citation information	RRID:IMSR_EM:12627 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NCrl-Spred1^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Spred1^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Spred1

Information from provider

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Legius syndrome / Orphanet_137605

IMPC phenotypes (allele matching)

abnormal vertebrae morphology / IMPC
increased neutrophil cell number / IMPC
abnormal heart morphology / IMPC
enlarged heart / IMPC
abnormal head morphology / IMPC
abnormal cranium morphology / IMPC
abnormal snout morphology / IMPC
abnormal maxilla morphology / IMPC
abnormal mandible morphology / IMPC
abnormal spleen morphology / IMPC
enlarged spleen / IMPC
enlarged lymph nodes / IMPC
abnormal thymus morphology / IMPC
enlarged thymus / IMPC
tremors / IMPC
abnormal ovary morphology / IMPC
small seminal vesicle / IMPC
decreased body weight / IMPC
anophthalmia / IMPC
abnormal retina morphology / IMPC
decreased locomotor activity / IMPC
abnormal startle reflex / IMPC
hydrocephaly / IMPC
abnormal seminal vesicle morphology / IMPC
abnormal skin morphology / IMPC
abnormal eye morphology / IMPC
abnormal tooth morphology / IMPC
abnormal brain morphology / IMPC
abnormal lymph node morphology / IMPC
increased thigmotaxis / IMPC
increased circulating alanine transaminase level / IMPC
decreased circulating alkaline phosphatase level / IMPC
abnormal bone structure / IMPC
increased kidney weight / IMPC
abnormal vertebral arch morphology / IMPC
vertebral fusion / IMPC
fusion of vertebral arches / IMPC
abnormal auditory brainstem response / IMPC
increased spleen weight / IMPC
decreased lymphocyte cell number / IMPC
abnormal zygomatic bone morphology / IMPC
increased circulating aspartate transaminase level / IMPC
increased circulating potassium level / IMPC
increased NK T cell number / IMPC
decreased grip strength / IMPC
increased circulating creatine kinase level / IMPC
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
increased effector memory CD8-positive, alpha-beta T cell number / IMPC
abnormal skin coloration / IMPC
abnormal head size / IMPC
increased CD4-positive NK T cell number / IMPC
increased memory-marker CD4-positive NK T cell number / IMPC
increased effector memory T-helper cell number / IMPC
increased freezing behavior / IMPC

IMPC phenotypes (gene matching)

abnormal spleen morphology / IMPC
increased CD4-positive NK T cell number / IMPC
increased circulating alanine transaminase level / IMPC
abnormal zygomatic bone morphology / IMPC
abnormal brain morphology / IMPC
abnormal snout morphology / IMPC
enlarged spleen / IMPC
vertebral fusion / IMPC
increased thigmotaxis / IMPC
hydrocephaly / IMPC
abnormal thymus morphology / IMPC
abnormal seminal vesicle morphology / IMPC
abnormal tooth morphology / IMPC
decreased body weight / IMPC
enlarged heart / IMPC
increased effector memory T-helper cell number / IMPC
increased spleen weight / IMPC
decreased grip strength / IMPC
decreased lymphocyte cell number / IMPC
abnormal vertebrae morphology / IMPC
abnormal head morphology / IMPC
increased circulating aspartate transaminase level / IMPC
abnormal bone structure / IMPC
abnormal mandible morphology / IMPC
abnormal maxilla morphology / IMPC
enlarged thymus / IMPC
abnormal heart morphology / IMPC
decreased circulating alkaline phosphatase level / IMPC
increased freezing behavior / IMPC
increased circulating creatine kinase level / IMPC
abnormal lymph node morphology / IMPC
abnormal auditory brainstem response / IMPC
increased neutrophil cell number / IMPC
anophthalmia / IMPC
abnormal startle reflex / IMPC
increased memory-marker CD4-positive NK T cell number / IMPC
tremors / IMPC
small seminal vesicle / IMPC
abnormal head size / IMPC
abnormal retina morphology / IMPC
abnormal ovary morphology / IMPC
fusion of vertebral arches / IMPC
abnormal vertebral arch morphology / IMPC
increased effector memory CD8-positive, alpha-beta T cell number / IMPC
abnormal skin morphology / IMPC
increased kidney weight / IMPC
abnormal eye morphology / IMPC
decreased locomotor activity / IMPC
increased NK T cell number / IMPC
abnormal cranium morphology / IMPC
abnormal skin coloration / IMPC
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
increased circulating potassium level / IMPC
enlarged lymph nodes / IMPC

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

C57BL/6NCrl-Spred1em1(IMPC)Ccpcz/Ph