- delayed bone ossification / MGI
- decreased compact bone thickness / MGI
- abnormal vertebral body morphology / MGI
- kyphosis / MGI
- scoliosis / MGI
- lordosis / MGI
- abnormal long bone hypertrophic chondrocyte zone / MGI
- megacephaly / MGI
- domed cranium / MGI
- abnormal small intestine morphology / MGI
- abnormal corpus callosum morphology / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal dentate gyrus morphology / MGI
- dilated lateral ventricles / MGI
- dilated third ventricle / MGI
- weight loss / MGI
- decreased body size / MGI
- delayed eyelid opening / MGI
- ataxia / MGI
- limb grasping / MGI
- hydroencephaly / MGI
- abnormal craniofacial bone morphology / MGI
- abnormal brain morphology / MGI
- no abnormal phenotype detected / MGI
- increased brain weight / MGI
- abnormal inner ear canal morphology / MGI
- abnormal cranial suture morphology / MGI
- abnormal bone mineralization / MGI
- abnormal long bone epiphyseal plate morphology / MGI
- delayed endochondral bone ossification / MGI
- abnormal long bone epiphyseal plate proliferative zone / MGI
- abnormal intervertebral disk morphology / MGI
- abnormal spine curvature / MGI
- intervertebral disk degeneration / MGI
- abnormal timing of postnatal eyelid opening / MGI
- craniofacial phenotype / MGI
- increased long bone epiphyseal plate size / MGI
- abnormal hippocampus CA1 region morphology / MGI
- slow postnatal weight gain / MGI
- enlarged lateral ventricles / MGI
- decreased trabecular bone thickness / MGI
- decreased trabecular bone mass / MGI
- lethality at weaning, incomplete penetrance / MGI
C57BL/6NTac-Nfixem5(IMPC)H/H
Status | Available to order |
EMMA ID | EM:12623 |
International strain name | C57BL/6NTac-Nfixem5(IMPC)H/H |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Nfixem5(IMPC)H |
Gene/Transgene symbol | Nfix |
Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mary Lyon Centre at MRC Harwell |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Malan overgrowth syndrome / Orphanet_420179
- Marshall-Smith syndrome / Orphanet_561
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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