STOCK CrygfRop/Ieg
| Status | Available to order |
| EMMA ID | EM:12545 |
| International strain name | STOCK CrygfRop/Ieg |
| Alternative name | Rop; CrygfRop |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | CrygfRop |
| Gene/Transgene symbol | Crygf |
Information from provider
| Provider | Jana Löster (formerly Kratochvilova) |
| Provider affiliation | Institut of Mammalian Genetics, Helmholtz Zentrum München |
| Additional owner | Prof. Dr. Jochen Graw, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Developmental Genetics, Neuherberg/Germany |
| Genetic information | Semi-dominant mutation in chromosome 1, gene Crygf (T113A; Val38Glu). Mutation generated by procarbazine. Disclaimer - Special restrictions: 1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols. 2) Some lines showed low penetrance of the phenotype. 3) Only sperm available. Rederivation service can not be offered. 4) EMMA quality control standards may not apply for these strains. 5) EMMA has not verified the breeding performance and the genetic background of the strains. The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt. |
| Phenotypic information | Homozygous:Total cataract.Heterozygous:Nuclear opacity with radial structures. |
| Breeding history | Kept as homozygotes. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Literature references
- Dominant cataract and recessive specific-locus mutations detected in offspring of procarbazine-treated male mice.;Kratochvilova J, Favor J, Neuhäuser-Klaus A, ;1988;Mutation research;198;295-301; 3352637
- Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity.;Graw Jochen, Klopp Norman, Neuhäuser-Klaus Angelika, Favor Jack, Löster Jana, ;2002;Investigative ophthalmology & visual science;43;2998-3002; 12202521