IMPC phenotypes (gene matching)
C57BL/6NTac-Gldcem1H/H
| Status | Available to order |
| EMMA ID | EM:12534 |
| International strain name | C57BL/6NTac-Gldcem1H/H |
| Alternative name | GLDC-S956Y-EM1-B6N |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Gldcem1H |
| Gene/Transgene symbol | Gldc |
Information from provider
| Provider | MRC-Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:Not knownHeterozygous:None reported |
| Breeding history | Co-isogenic on original background |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Atypical glycine encephalopathy / Orphanet_289863
- Neonatal glycine encephalopathy / Orphanet_289857
- Infantile glycine encephalopathy / Orphanet_289860
Literature references
- Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia.;Leung Kit-Yi, De Castro Sandra C P, Santos Chloe, Savery Dawn, Prunty Helen, Gold-Diaz Diana, Bennett Stuart, Heales Simon, Copp Andrew J, Greene Nicholas D E, ;2020;Journal of inherited metabolic disease;43;1186-1198; 32743799